李瑞峰,陈天乐

高原地区独特的气候及低氧环境，使得心血管疾病的发病率明显高于平原地区，同时在高原地区OSAHS患者心血管疾病的发生呈现早发性，往往更为严重致残率及死亡率，CPAP的出现也为此类人群提供了更好的治疗策略，但相关人群的认知度及接受度亟需加强健康教育与科普宣传。

高原地区；睡眠呼吸暂停综合症；心血管疾病

[1] 杨生岳,戴胜归,冯恩志,等.高原地区阻塞性睡眠呼吸暂停低通气综合征患者肺动脉高压与血管内皮功能的关系及CPAP的干预作用[J].中华肺部疾病杂志(电子版),2014,7(3). [2] 王利霞,肖毅.睡眠呼吸障碍年度进展2025[J].中华结核和呼吸杂志,2026,49(2):198-205. [3] Li H,Pan Y,Lou Y,et al.The Effects of Continuous Positive Airway Pressure Therapy for Secondary Cardiovascular Prevention in Patients with Obstructive Sleep Apnoea:A Systematic Review and Meta-Analysis[J].Reviews in Cardiovascular Medicine,2022,23(6). [4] Katyal V,Pamula Y,Martin A J,et al.Craniofacial and upper airway morphology in pediatric sleep-disordered breathing:Systematic review and meta-analysis[J].American Journal of Orthodontics&Dentofacial Orthopedics,2013,143(1). [5] 雷祖宝,吕志.CPAP对中重度OSAS合并右心衰竭的疗效观察[J].临床肺科杂志,2013,18(11):2. [6] Sanders M H,Newman A B,Haggerty C L,et al.Sleep and Sleep-disordered Breathing in Adults with Predominantly Mild Obstructive Airway Disease[J].American Journal of Respiratory and Critical Care Medicine,2003,167(1):7-14. [7] B,A,Malow,et al.Treating obstructive sleep apnea in adults with epilepsy:A randomized pilot trial[J].Neurology,2008,71(8). [8] 侯雅新,林飞,李奕帛,等.氧化应激在动脉粥样硬化发病中的作用研究进展[J].新乡医学院学报,2021(038-011). [9] Chaoya W,Liecheng W,Shengchun X U,et al.Relationship between Sleep Disorders and Vitamin D Deficiency:a Meta-analysis[J].Chinese General Practice,2019. [10] 吴献懿,王晓,范婧尧,等.阻塞性睡眠呼吸暂停严重程度与冠状动脉粥样硬化性心脏病患者冠状动脉病变的相关性[J].中国医药,2018,13(3):5. [11] Kinjo Y,Kurita N,Nakamura F,et al.Effectiveness of combined thoracoscopic-laparoscopic esophagectomy:comparison of postoperative complications and midterm oncological outcomes in patients with esophageal cancer.[J].Surgical Endoscopy&Other Interventional Techniques,2012,26(2):381-390. [12] Branco A F,AndréFerreira,Simes R F,et al.Ketogenic Diets:From Cancer To Mitochondrial Diseases And Beyond[J].European Journal of Clinical Investigation,2016,46(3):285-298. [13] Mega J L,Braunwald E,Murphy S A,et al.Rivaroxaban in patients stabilized after a ST-segment elevation myocardial infarction:results from the ATLAS ACS-2-TIMI-51 trial(Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Throm[J].Journal of the American College of Cardiology,2013,61(18):1853-1859. [14] 向东,唐璐谭.高原地区睡眠呼吸障碍特征及治疗的研究进展[J].Journal of Sichuan University(Medical Sciences),2023,54(2):246-246. [15] Salman L A,Shulman R,Cohen J B.Obstructive Sleep Apnea,Hypertension,and Cardiovascular Risk:Epidemiology,Pathophysiology, and Management[J].Current Cardiology Reports,2020,22(2):1-9. [16] 杨生岳,冯恩志,闫自强,等.高原肺水肿患者肺血管活性因子水平变化及其与肺动脉高压的关系[J].中华肺部疾病杂志:电子版, 2011,4(1):4. [17] 陈震姜,嵩周琦,刘锦辉.阻塞性睡眠呼吸暂停低通气综合征患者认知功能改变与血清HIF-1α和VEGF的相关性分析[J].江西医药,2022,57(9):1110-1112. [18] 许亚慧,刘凤娟,王立生,等.阻塞性睡眠呼吸暂停低通气综合征与心血管疾病相关性的研究进展[J].临床肺科杂志,2019,24(7):4. [19] 孙静,陈莉,怀德,等.阻塞性睡眠呼吸暂停低通气综合征患者发生心血管疾病风险的因素分析[J].心血管康复医学杂志,2024, 33(5):546-549. [20] 吴雪,马晓峰.高原地区睡眠呼吸暂停综合征合并动脉粥样硬化关系的研究进展[J].高原医学杂志,2024(2):59-63. [21] 雷鹏鹏,刘存,陈帅,等.阻塞性睡眠呼吸暂停对心血管疾病的影响与治疗的研究进展[J].中国循证心血管医学杂志,2025(7) [22] 曾晓杰.阻塞性睡眠呼吸暂停综合征患者房性心律失常的发生与V_1导联P波终末电势的相关性分析[D].甘肃中医药大学,2020. [23] 刘敏,张文理,张锐,等.高血压病合并OSA患者睡眠结构对血压节律的影响[J].临床心血管病杂志,2020(011):036. [24] 徐青霞,张丽萍,陆华东.阻塞性睡眠呼吸暂停综合征共病心血管疾病的危险因素及血清Nesfatin-1､Omentin-1､HIF-1α的诊断价值[J/OL].重庆医学.

点击下载PDF