曾文驰,陈鸣娣,董宏裕,江国栋,黎焯基

目的：探讨重症急性胰腺炎（SAP）并发脓毒症患者血清中高迁移率族蛋白B1（HMGB1）、白细胞介素-6（IL-6）及信号转导与转录激活因子3（STAT3）水平与临床预后的相关性。方法：前瞻性纳入2022年9月至2023年9月收治的84例SAP合并脓毒症患者，根据脓毒性休克诊断标准分为普通脓毒症组（58例）和脓毒症休克组（26例）。采用ELISA法检测两组患者入院24小时内血清HMGB1、IL-6及STAT3水平，比较组间差异并分析28天内病死率。结果：脓毒症休克组的血清HMGB1、IL-6 和STAT3水平分别为81.16±15.62 ng/mL、142.16±29.45 pg/mL、1.76±0.41 pg/mL，较普通组分别升高1.78、1.39和1.52倍（P<0.01）。脓毒症休克组患者28天内病死率为42.31%（11/26），显著高于普通组的20.69%（12/58）（χ²=5.307，P=0.011）。结论：HMGB1/IL-6/STAT3信号通路激活程度与SAP合并脓毒症患者的病情严重程度及不良预后显著相关，联合检测可能为早期识别高危患者提供生物标志物组合。

脓毒症；重症急性胰腺炎；高迁移率族蛋白B1；白细胞介素6；STAT3转录因子

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