汪正河,王献珍

耐甲氧西林金黄色葡萄球菌（MRSA）感染，已然成为全球公共卫生领域面临的重大威胁，传统抗生素的治疗效果正逐渐变弱，当下迫切需要开发新型抗菌药物来应对这一难题[1]，GyrA作为MRSA的关键靶点，开发其抑制剂对于抗击MRSA感染有着意义[2]，近些年来，模态虚拟筛选方法凭借其高效以及精准的特性，成为筛选可靶向抑制MRSA GyrA靶点抗菌药物的关键工具。本文对模态虚拟筛选方法的基本原理、技术流程以及在MRSA GyrA靶点药物筛选中的优势进行了综述，还总结了最新的研究进展，凭借对现有文献展开综合分析，本文可为新型抗MRSA药物的开发提供理论依据与技术参考，期望能为抗击耐药性细菌感染提供新的解决办法。

模态虚拟筛选；耐甲氧西林金黄色葡萄球菌；GyrA；抗菌药物；分子对接

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