Chengmei Ye,Yongli Yang

Objective: To investigate the effects of hypoxic environment on ovulatory dysfunction and hyperandrogenemia in patients with polycystic ovary syndrome living at high altitude, and to provide a theoretical basis for the clinical treatment of polycystic ovary syndrome in high-altitude areas. Methods: A total of 86 patients with polycystic ovary syndrome admitted to our hospital from January 2025 to January 2026 were selected as research subjects and divided into a control group and an observation group according to residential environment, with 43 cases in each group. The control group consisted of patients living in plain areas, and the observation group consisted of patients living in a high-altitude hypoxic environment. Indicators related to ovulatory function, hyperandrogenemia and hypoxia were compared between the two groups, and statistical methods were used to analyze the differences between the two groups of data. Results: The ovulation rate (23.26%) in the observation group was significantly lower than that in the control group (48.84%), and the incidence of oligomenorrhea (58.14%) and amenorrhea (25.58%) was significantly higher than that in the control group (27.91%, 6.98%), with statistically significant differences. The levels of testosterone (3.12±0.68 nmol/L) and androstenedione (9.76±1.58 nmol/L) in the observation group were significantly higher than those in the control group (2.35±0.52 nmol/L, 7.82±1.35 nmol/L), while the estradiol level (125.38±22.19 pmol/L) was significantly lower than that in the control group (158.63±25.47 pmol/L), with statistically significant differences. The blood oxygen saturation (88.35±2.16%) in the observation group was significantly lower than that in the control group (96.52±1.23%), and the red blood cell count (5.67±0.58×10¹²/L) was significantly higher than that in the control group (4.58±0.42×10¹²/L), with statistically significant differences. Conclusion: Chronic hypoxia in plateau regions exacerbates ovulatory dysfunction and hyperandrogenism in patients with PCOS. Clinical management strategies should be tailored to hypoxic conditions to improve physiological outcomes in this population.

Hypoxic environment; High altitude; Polycystic ovary syndrome; Ovulatory dysfunction; Hyperandrogenemia

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