苏赢琳,陈桃英

目的：分析探讨早产儿发生新生儿坏死性小肠结肠炎（Neonatal necrotizing enterocolitis，NEC）的高危因素，寻找有效预测指标，为NEC的预防提供新的循证医学证据。方法：选取本院2016年12月~2024年8月的71例＜37周的早产儿，根据是否发展为NEC，分为对照组及NEC组。对比2组早产儿一般资料、孕母临床资料、发生NEC前的基础疾病及治疗措施，入院24小时内血常规、生化结果，应用多因素Logistic回归分析早产儿发生NEC的独立危险因素。结果：SNAPPE-Ⅱ评分越高、白细胞计数越高、血钠水平减低、无创呼吸机使用天数≥7d是早产儿发生NEC的独立危险因素，P<0.05。结论：我们在早产儿诊治过程中，应重视SNAPPE-Ⅱ评分的应用，动态监测白细胞计数及血钠水平，评估呼吸支持的必要性，尽可能预防NEC的发生，早发现、早治疗，改善早产儿救治的整体预后。

早产儿；新生儿坏死性小肠结肠炎；SNAPPE-Ⅱ评分；血钠；白细胞计数

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