鲁嘉良,魏 莎,刘 路

目的：探讨富血小板血浆（PRP）对创伤后异位骨化（HO）的抑制作用。方法：32只雄性Wistar大鼠，16只制备PRP，其余随机分为模型对照组（A组）和PRP组（B组），每组8只。A组通过跟腱钝挫伤加切断建立HO模型；B组在建模后局部注射PRP。术后10周通过影像学、HE染色评估异位骨形成。结果：一般情况、影像学表现、HE染色均表明A组建模成功，并且得到了稳定的结果。影像学观察术后10周，A组全部出现明显的异位骨形成，B组仅4只出现明显骨化表现，A组与B组比较，差异有统计学意义（P＜0.05）。HE染色：A组全部出现异位骨化，B组仅50%发生（P<0.05）。HE染色显示A组以骨细胞软骨内形成为主，B组以纤维组织和部分软骨骨岛为主。结论：富血小板血浆对大鼠创伤后跟腱炎症反应及异位骨化的发生有抑制作用。

富血小板血浆；跟腱；创伤；异位骨化

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