万贻麟,石雪峰

阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是指在睡眠期间反复发生部分或完全上呼吸道阻塞，导致间歇性缺氧和睡眠碎片化，并导致机体多系统靶器官功能受损。血浆（及血清）作为沟通全身组织器官的“信息枢纽”，能够动态、综合地反映机体在OSAHS病理状态下的整体代谢表型。近年来，基于血浆/血清的代谢组学研究为揭示OSAHS的系统性代谢紊乱机制、发现具有诊断和预后价值的生物标志物提供了强有力的工具。本文系统综述了OSAHS血浆代谢组学的研究进展，探讨了这些代谢标志物在疾病辅助诊断、严重程度评估、心血管及代谢并发症风险预测中的潜在应用价值，推动该疾病的进一步研究。

阻塞性睡眠呼吸暂停低通气综合征；血浆；代谢组学

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