代谢物检测在白癜风病情评估中的应用价值

ISSN:2811-051X(P)

EISSN:2811-0781(O)

语言:中文

作者
马文礼,陈旌凤,高如宏,杨占录,廉凤霞
文章摘要
本文梳理代谢物检测与白癜风发病机制的关联、在病情评估中的临床应用价值。主要从氨基酸、脂质、能量、肠道菌群衍生等代谢途径探讨与白癜风发病相关性。为白癜风精准评估提供参考,助力临床诊疗优化。
文章关键词
代谢物检测;白癜风;病情评估;黑素细胞;免疫炎症;氧化应激
参考文献
[1] Rezvan Marzabani,et al.Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo[J].Metabolomics,2021,17(10):92. [2] James M.Phang.Proline Metabolism in Cell Regulation and Cancer Biology:Recent Advances and Hypotheses[J].Antioxid Redox Signal,2019,30(4):635-649. [3] Jolanta Pekala,et al.L-carnitine--metabolic functions and meaning in humans life[J].Curr Drug Metab,2011,12(7):667-678. [4] M.A.de Pablo,et al.The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice[J].J Nutr Sci Vitaminol(Tokyo),1998,44(1):57-67. [5] D.S.Kelley,et al.Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men[J].Lipids,1999,34(4):317-324. [6] Daniela Kovacs,et al.Vitiligo Skin:Exploring the Dermal Compartment[J].J Invest Dermatol,2018,138(2):394-404. [7] Thamer M,Ahmed A,Sanjeev M,Salma A,Mohammed Y,Mohammed A.Association of vitiligo with anemia,vitamin B12 deficiency,diabetes mellitus,and thyroid dysfunction in Saudi Arab patients:A case control study.J Dermatol Dermatologic Surg(2017)21(2):72–6.[J]. [8] Shajil Em,et al.Association of catalase T/C exon 9 and glutathione peroxidase codon 200 polymorphisms in relation to their activities and oxidative stress with vitiligo susceptibility in Gujarat population[J].Pigment Cell Res,2007,20(5):405-407.[9] Mao Lin,et al.Regulatory T cells from active non-segmental vitiligo exhibit lower suppressive ability on CD8+CLA+T cells[J].Eur J Dermatol,2014,24(6):676-682. [10] Hamid Mostafavi Abdolmaleky,Jin-Rong Zhou.Gut Microbiota Dysbiosis,Oxidative Stress,Inflammation,and Epigenetic Alterations in Metabolic Diseases[J].Antioxidants(Basel),2024,13(8). [11] Hsin-Jou Kao,et al.Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis[J].Sci Rep,2021,11(1):11980. [12] Archana Singh,et al.Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligo[J].Sci Rep,2017,7(1):9860.
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