吴艳欣,洪嘉俊

目的：探讨溶木聚糖拟杆菌与妊娠期糖尿病孕妇血糖、GLP-1以及PYY的相关性。方法：本研究纳入在中山大学附属第一医院产检的单胎妊娠孕妇，在妊娠24-28周收集孕妇的血液和粪便，测定血清中的GLP-1和PYY的浓度和粪便中溶木聚糖拟杆菌的相对丰度。结果：本研究纳入孕妇56例，其中GDM组27例，非GDM组29例。溶木聚糖拟杆菌在GDM的相对丰度比非GDM组明显下降（P<0.05）。溶木聚糖拟杆菌的相对丰度与空腹血糖无相关性（P>0.05），与OGTT-1小时血糖呈负相关性（r=-0.34，P=0.01），与OGTT-2小时血糖呈负相关性（r=-0.32，P=0.015）。溶木聚糖拟杆菌与GLP-1无相关（r=-0.1，P=0.471），但与PYY呈正相关性（r=0.28，P=0.034）。结论：溶木聚糖拟杆菌可能影响GDM孕妇PYY的分泌，参与血糖调控。

妊娠期糖尿病；拟杆菌；酪酪肽

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