作者
李如梅
文章摘要
目的:通过分析一例甲状腺弥漫大B细胞淋巴瘤的临床表现、超声影像学特征及病理诊断,增强对原发性甲状腺淋巴瘤的识别和诊治能力。方法:回顾性分析一例73岁男性患者,因颈部肿块迅速增大就诊,结合体格检查、实验室指标、超声检查及穿刺病理结果进行诊断,并复习相关文献。结果:患者颈部肿块快速生长,超声提示右叶显著增大、回声减低并伴丰富血流信号,穿刺活检证实为弥漫大B细胞淋巴瘤(GCB型),最终明确诊断并转入血液科进一步治疗。结论:原发性甲状腺淋巴瘤临床少见,常表现为甲状腺迅速肿大,需与未分化癌、桥本甲状腺炎及甲状腺乳头状癌等鉴别。超声检查结合细针或粗针穿刺活检有助于早期诊断。提高临床对该病的警觉性,有助于及时干预、改善预后。
文章关键词
甲状腺淋巴瘤;弥漫大B细胞淋巴瘤;穿刺活检;超声;个案报告
参考文献
[1] Travaglino A,Pace M,Varricchio S,et al.Hashimoto thyroiditis in primary thyroid Non-Hodgkin lymphoma:a systematic review and meta-analysis.Am J Clin Pathol.2020;153(2):156–64.
[2] Vardell Noble V,Ermann DA,Grifn EK,et al.Primary thyroid lymphoma:an analysis of the national cancer database.Cureus.2019;11(2):e4088.
[3] Katna R,Shet T,Sengar M,et al.Clinicopathologic study and outcome analysis of thyroid lymphomas:experience form a tertiary cancer center.Head Neck.2013;35:165–71.
[4] Yang L,Zhao H,He Y,et al.Contrast-enhanced ultrasound in the diferential diagnosis of primary thyroid lymphoma and nodular Hashimoto’s thyroiditis in a background of heterogeneous parenchyma.Front Oncol.2020;10:597975.
[5] Sakorafas GH,Kokkoris P,Farley DR.Primary thyroid lympoma:Diagnostic and therapeutic dilemmas.Surgical oncology.2010;19(4):e124-9.
[6] Sakorafas GH,Peros G.Thyroid nodule:a potentially malignant lesion;optimal management from a surgical perspective.Cancer Treat Rev 2006;32:191e202.
[7] 张秀梅,农琳,冉旭,等.甲状腺淋巴瘤临床病理及超声特征分析[J].中华医学杂志,2017,97(37):2936⁃2939.
[8] 胡景.甲状腺淋巴瘤与甲状腺未分化癌的临床、超声及病理对照分析[D].山西医科大学,2018.
[9] Liu L,Yu Y,Chen L,et al.Clinical differences between IgG4 Hashimoto’s thyroiditis and primary thyroid lymphoma.European Thyroid Journal.2022 Jun 1;11(3).
[10] Peng C,Yang C,Yao J,et al.Multimodal Sonographic Appearance and Survival outcomes of 69 cases of primary thyroid Lymphoma over 10 years.Journal of Ultrasound in Medicine.2022 Dec;41(12):3031-40.
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