蔺童童,杨发满

骨关节炎与肌少症被认为是老年综合征中的一类共病簇，直接导致老年衰弱、跌倒、失能、心血管恶性事件甚至病死。越来越多证据表明，骨关节炎与肌少症间的关联紧密，共同促发且关联机制复杂。其中包括多分子机制参与，如差异表达基因（DEGs）：FOXO3、CDKN1A、CEBPB等。它们相互串扰、加速进展，并最终导致恶性循环。鉴于目前仍未有切实有效的肌少症治疗策略，本文对这两类疾病内在关联的分子机制的研究进展进行综述，以期为找到有效干预方法提供新途径。

骨关节炎；肌少症；差异表达基因；研究进展

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