顾章媛,莊志刚

配子（哺乳动物的精子和卵子）的产生涉及两次连续的细胞分裂，即减数分裂 I 和减数分裂 II。在减数分裂 I 中，同源染色体分离到不同的子细胞，减数分裂 II 类似于有丝分裂，姐妹染色单体分开。虽然原则上男性和女性的过程是相同的，但时间范围和对染色体缺陷的易感性（包括失染色体和内聚力减弱）以及对错误分离染色体的反应却不同。在这篇综述中，我们比较和对比了两种性别的减数分裂纺锤体组装检查点功能和非整倍性。

减数分裂；染色体分离；凝聚素

[1] Stefano,Santaguida,Angelika,et al.Short-and long-term effects of chromosome mis-segregation and aneuploidy[J].Nature reviews Molecular cell biology,2015. [2] Brooker A S,Berkowitz K M.The Roles of Cohesins in Mitosis,Meiosis,and Human Health and Disease[J].Methods Mol Biol,2014,1170:229-66. [3] Kauppi L,Barchi M,Lange J,et al.Numerical constraints and feedback control of double-strand breaks in mouse meiosis[J].Genes&Development,2013,27(8). [4] Gray S,Cohen P E.Control of Meiotic Crossovers:From Double-Stand Break Formation to Designation[J].Annual Review ofGenetics,2016,50(1). [5] Lane S I R,Jones K T.Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes[J].Nature communications,2014,5.

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