社区中老年人群亚临床动脉粥样硬化流行情况及风险因素分析

ISSN:2811-051X(P)

EISSN:2811-0781(O)

语言:中文

作者
胡美芝,袁子宇,李佳琳,蒋艳峰,陈兴栋
文章摘要
目的:调查分析泰州市农村社区中老年人群亚临床动脉粥样硬化的患病情况及风险因素。方法:利用泰州脑影像队列的基线横断面流行病学调查资料和血管超声检查数据,分析55-65岁人群亚临床动脉粥样硬化的患病情况。进一步采用多因素Logistic回归分析人口学特征、生活方式、慢性病等因素与亚临床动脉粥样硬化的关联。结果:本研究共纳入899名研究对象,增龄(OR:1.09,95%;CI:1.03-1.14)、高血压(OR:4.98,95%;CI:3.58-7.00)、糖尿病(OR:5.25,95%;CI:2.67-11.90)和代谢综合征(OR:3.07,95%;CI:2.08-4.63)与亚临床动脉粥样硬化风险增加显著相关。结论:年龄与亚临床动脉粥样硬化密切相关,高血压、糖尿病、血脂异常等可作为可控的危险因素进行干预。
文章关键词
动脉粥样硬化;社区人群;危险因素
参考文献
[1] Fan J, Watanabe T. Atherosclerosis: Known and unknown [J]. Pathol Int, 2022, 72(3): 151-60. [2] Takei H, Strong J P, Yutani C, et al. Comparison of coronary and aortic atherosclerosis in youth from Japan and the USA [J]. Atherosclerosis, 2005, 180(1): 171-9. [3] Falk E. Pathogenesis of atherosclerosis [J]. J Am Coll Cardiol, 2006, 47(8 Suppl): C7-12. [4] Kim J, Song T J, Song D, et al. Brachial-ankle pulse wave velocity is a strong predictor for mortality in patients with acute stroke [J]. Hypertension (Dallas, Tex : 1979), 2014, 64(2): 240-6. [5] Diehm C, Allenberg J R, Pittrow D, et al. [Importance of the ankle-brachial index (ABI) in the prevention of cardiovascular diseases. Ten questions and answers] [J]. Herz, 2007, 32(5): 404-9. [6] Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis [J]. Journal of the American College of Cardiology, 2010, 55(13): 1318-27. [7] Jiang Y, Cui M, Tian W, et al. Lifestyle, multi-omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study [J]. Alzheimers Dement, 2021, 17(1): 18-28. [8] Wang X, Lu M, Qian J, et al. Rationales, design and recruitment of the Taizhou Longitudinal Study [J]. BMC Public Health, 2009, 9: 223. [9] Sillesen H, Sartori S, Sandholt B, et al. Carotid plaque thickness and carotid plaque burden predict future cardiovascular events in asymptomatic adult Americans [J]. Eur Heart J Cardiovasc Imaging, 2018, 19(9): 1042-50. [10] Jiang Y, Zhang K, Zhu Z, et al. Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study [J]. Aging, 2020, 12(15): 15302-13. [11]《中国心血管病报告2010》概要[J].护理管理杂志,2012,12(01):14-5. [12] Safar M E, Levy B I, Struijker-Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases [J]. Circulation, 2003, 107(22): 2864-9. [13] Ma R C W. Epidemiology of diabetes and diabetic complications in China [J]. Diabetologia, 2018, 61(6): 1249-60. [14] Bragg F, Holmes M V, Iona A, et al. Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China [J]. Jama, 2017, 317(3): 280-9. [15] Paneni F, Beckman J A, Creager M A, et al. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I [J]. Eur Heart J, 2013, 34(31): 2436-43. [16] Esposito K, Giugliano D, Nappo F, et al. Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus [J]. Circulation, 2004, 110(2): 214-9. [17] Borén J, Chapman M J, Krauss R M, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel [J]. Eur Heart J, 2020, 41(24): 2313-30. [18]《中国居民营养与慢性病状况报告(2015年)》发布[J].上海预防医学,2016,28(03):141. [19] Koskinas K C, Mach F, Räber L. Lipid-lowering therapy and percutaneous coronary interventions [J]. EuroIntervention, 2021, 16(17): 1389-403. [20] Shatnawi A, Kamran Z, Al-Share Q. Pharmacogenomics of lipid-lowering agents: the impact on efficacy and safety [J]. Per Med, 2022.
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