蒋 艳,姚 波

目的：采用两样本孟德尔随机化（MR）评价循环炎症蛋白、血浆代谢性状与卵巢过度刺激综合征（OHSS）风险的遗传关联，并探索候选炎症-代谢路径。方法：纳入91种循环炎症蛋白、1400项血浆代谢性状及OHSS GWAS（695例病例、290 351例对照）。以逆方差加权法（IVW）为主；炎症蛋白以IVW P＜0.05探索性筛选，代谢性状行Benjamini-Hochberg错误发现率（FDR）校正；对候选蛋白开展反向MR及两步MR。结果：筛出8种IVW名义显著的探索性候选炎症蛋白，S100-A12、CXCL9和MIP-1α呈风险方向，ST1A1、CST5、LIF-R、MMP-1和AXIN1呈保护方向。FDR校正后46项代谢性状与OHSS风险存在遗传关联，其中29项呈风险方向、17项呈保护方向。反向IVW结果均P＞0.05。16条候选炎症-代谢路径的间接效应95%CI均跨0；S100-A12-alpha-ketoglutarate/aspartate ratio-OHSS链路间接效应为0.0380（95%CI：-0.0557～0.132）。结论：部分炎症蛋白与OHSS呈探索性关联，46项代谢性状获得FDR校正后的关联证据，尚无显著中介证据。

卵巢过度刺激综合征；循环炎症蛋白；血浆代谢性状；孟德尔随机化；中介分析

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