刘 薇,黄 丹,刘 丹,赵周英

手足寻常疣由人乳头瘤病毒感染引起。掌跖部位角质层较厚，又长期承受摩擦和压力，部分病灶消退较慢，治疗后疼痛、复发及功能受限也更常见。液氮冷冻主要依靠低温破坏疣体组织，5-氟尿嘧啶则通过抑制异常增殖细胞发挥作用，两者作用环节不同，为联合应用提供了可能。现有文献对两种方法单独治疗的报道较多，但联合方案在剂量、时序、疗程和安全性方面仍缺少统一认识。本文结合手足寻常疣的临床特点，对冷冻和局部5-氟尿嘧啶的适用情形、疗效影响因素及不良反应进行比较，并讨论联合治疗的实际价值。临床判断不能只看疣体是否清除，还要结合疼痛、功能恢复、复发和患者依从性综合评价。

寻常疣；5-氟尿嘧啶；冷冻治疗；局部注射；疗效；安全性

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