蒋 艳,姚 波

目的：采用双向两样本孟德尔随机化（MR）评价肠道菌群性状、循环炎症蛋白与卵巢过度刺激综合征（OHSS）风险的遗传关联，并探索候选菌群-炎症蛋白链路。方法：纳入473项肠道菌群GWAS性状、91种循环炎症蛋白及OHSS GWAS（695例病例、290 351例对照）。以逆方差加权法（IVW）为主，对菌群和蛋白主分析P值分别行Benjamini-Hochberg错误发现率（FDR）校正，并开展敏感性、反向MR和两步MR。结果：FDR校正后23项菌群性状与OHSS相关，其中13项呈风险方向、10项呈保护方向；CX3CL1、IL-24、LIF-R呈保护方向，NRTN呈风险方向（均P_FDR＜0.05）。反向MR未获得FDR校正后的显著关联。Chromatiales丰度升高与NRTN水平升高相关（OR=1.8059，95%CI：1.0716～3.0436，P=0.0265），但间接效应不显著（β=0.3342，95%CI：-0.0665～0.7349，P=0.102）。结论：部分肠道菌群性状及循环炎症蛋白与OHSS易感性存在遗传关联，Chromatiales- NRTN-OHSS可作为候选链路，但尚无显著中介证据。

卵巢过度刺激综合征；肠道菌群；循环炎症蛋白；孟德尔随机化

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