苏广锐,黄炳臣

目的：探讨原发性子宫尤文肉瘤（Ewing sarcoma，ES）的临床病理特征、免疫组化、诊断和鉴别诊断要点。方法：对1例原发性子宫尤文肉瘤进行组织学、免疫组化和FISH观察，并复习相关文献。结果：患者女性，30岁,肿瘤原发于子宫，切面灰红灰白、实性、质中，镜下肿瘤细胞呈小圆形、卵圆形或小多边形，细胞异型性明显，核染色质空泡状、核仁突显，核分裂象易见，呈小叶状分布，可见灶状坏死，小叶间为宽窄不等的纤维性间隔。瘤细胞表达Vimentin、CD99、Syn，Ki67增殖指数约50%；FISH检测EWSR1基因易位为阳性。肿瘤彻底切除后规范化疗，随访15个月未发现转移和复发。结论：子宫的尤文肉瘤罕见，应与高级别子宫内膜间质肉瘤、腺泡状横纹肌肉瘤、小细胞神经内分泌癌和小圆细胞肉瘤等鉴别。

尤文肉瘤；神经外胚层瘤；子宫；EWSR1基因

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