李 智,李丽华,王 博,刘 岩,刘伟静

目的：评价手术显微镜图像采集处理系统（EndoSCell Scanner，ES；DDB-5）在乳腺癌及甲状腺癌手术中进行细胞级切缘判读的准确性、时效性及临床可行性。方法：前瞻性、单中心、自身对照研究。纳入2026年于佳木斯市肿瘤医院行手术的乳腺癌及甲状腺癌患者16例，共选取47个样本。所有样本均行ES、术中快速冰冻病理（Frozen section，FS）及石蜡病理（HE）检查。以HE为金标准，分析ES与FS的诊断效能、一致性及耗时差异。结果：ES诊断灵敏度100.0%，特异度96.9%，准确性97.9%，AUC为0.984，不劣于FS。ES与FS判读结果Kappa值为0.952，三者间Kappa值为0.935，提示极好一致性。ES均值2.57±1.00分钟，显著短于FS的23.19±8.48分钟（P<0.001），平均每样本节省约20.62分钟。结论：DDB-5在乳腺癌及甲状腺癌手术切缘判读中准确性与FS高度一致，判读速度显著提升，有望作为传统FS的有效补充。

乳腺癌；甲状腺癌；术中诊断；EndoSCell

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