单铄翔,王汉青,郝丽英,陈思充

本文围绕线粒体自噬的两类通路（PINK1/Parkin介导的泛素依赖性通路与BNIP3/NIX、FUNDC1等受体介导通路），结合mTOR、AMPK及Ca²⁺/CaMKII等调控轴，梳理其在线力衰竭/心肌肥厚、动脉粥样硬化与缺血性心肌损伤中的相关机制与表现，并汇总辛伐他汀、利拉格鲁肽、二甲双胍及白藜芦醇、槲皮素、姜黄素、褪黑素等通过调控线粒体自噬产生心脏保护作用的研究进展，为靶向线粒体自噬的干预策略提供参考。

线粒体自噬；心血管疾病

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