脓毒症性凝血病中西医研究进展

ISSN:2705-098X(P)

EISSN:2705-0505(O)

语言:中文

作者
魏凡博,杨益宝
文章摘要
脓毒症是由感染引起的一种全身性炎症反应综合征,脓毒症性凝血病(SIC)是脓毒症导致的血管内皮细胞损伤和凝血紊乱,是影响脓毒症患者预后的一个关键因素。临床上中西医结合治疗具有独特优势。本文综合现有文献,阐述当前脓毒症性凝血病的中西医治疗研究进展,为临床治疗提供了参考和启示。
文章关键词
脓毒症;脓毒症性凝血病;中西医治疗
参考文献
[1] H W,J T,M N D,et al.Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.[J].Journal of thrombosis and haemostasis,2013,11(4):761-767. [2] 宋景春,丁仁彧,吕奔,等.脓毒症性凝血病诊疗中国专家共识(2024版)[J].解放军医学杂志,2024,49(11):1221-1236. [3] Zhu L,Dong H,Li L,et al.The Mechanisms of Sepsis Induced Coagulation Dysfunction and Its Treatment[J].Journal of Inflammation Research,2025,18:1479-1495. [4] Carcillo J A,Shakoory B.Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome[J].Advances in experimental medicine and biology,2024,1448:441-457. [5] S B,A F,T K.Routine coagulation tests on ICU admission are associated with mortality in sepsis:an observational study.[J].Acta anaesthesiologica Scandinavica,2017,61(7):790-796. [6] Østerud B,Bjørklid E.The tissue factor pathway in disseminated intravascular coagulation.[J].Seminars in thrombosis and hemostasis, 2001,27(6):605-617. [7] Yu J M,Hui J Z,Wei C,et al.Effects of Neutrophil Extracellular Traps in Patients With Septic Coagulopathy and Their Interaction With Autophagy[J].Frontiers in Immunology,2021,12:757041. [8] Naveen N.Sepsis-Induced Coagulopathy:A Prelude to DIC[J].Anesthesia&Analgesia,2024,138(4):695. [9] Ryan T A J,O'Neill L A J.Innate immune signaling and immunothrombosis:New insights and therapeutic opportunities[J].European Journal of Immunology,2022,52(7):1024-1034. [10] 何丹,主有峰,王珊,等.低分子肝素对脓毒症患者预后及出血风险的Meta分析[J].中国感染控制杂志,2018,17(08):670-678. [11] 林青伟,宋景春,彭恩兰,等.应用甲磺酸萘莫司他治疗脓毒症性凝血病的探讨[J].血栓与止血学,2023,29(03):138-142. [12] 江培猛.小剂量糖皮质激素在脓毒性休克中的应用[J].现代诊断与治疗,2019,30(07):1011-1012. [13] Schmidt C,Weißmüller S,Heinz C C.Multifaceted Tissue-Protective Functions of Polyvalent Immunoglobulin Preparations in Severe Infections—Interactions with Neutrophils,Complement,and Coagulation Pathways[J].Biomedicines,2023,11(11):3022. [14] 袁婷,曾俊,江华.静脉高剂量维生素C用于脓毒症治疗:从分子机制到临床应用[J].实用医院临床杂志,2023,20(05):201-204. [15] 李俊美,姚成东.乌司他丁治疗重症脓毒症患者的临床效果观察[J].中国实用医药,2022,17(26):115-117. [16] Songlin W,Tao X,Changxue W,et al.Continuous renal replacement therapy in sepsis-associated acute kidney injury:Effects on inflammatory mediators and coagulation function.[J].Asian journal of surgery,2021,44(10):1254-1259. [17] 李巧,倪敏,颜玉颖,等.替加环素致凝血功能异常的临床回顾分析[J].药物流行病学杂志,2024,33(10):1099-1106. [18] 沈艺宏,杨卓,刘世平.成人脓毒症抗感染治疗研究进展[J].华西医学,2021,36(11):1598-1602. [19] 中华中医药学会.中医内科临床诊疗指南[M].北京:中国中医药出版社,2020:236. [20] 巩美鱼,刘保社,段淑琴,等.脓毒症凝血功能障碍患者中医证型与预后相关性研究[J].中国中医急症,2016,25(10):1934-1936. [21] 郭楠,刘清泉,江其敏,等.基于气血相关理论脓毒症凝血功能障碍临床研究[J].中国中医药现代远程教育,2010,8(18):145-147. [22] 赵锋利,赵馥,张先进,等.调胃承气汤对肠源性脓毒症大鼠血液流变学指标和凝血功能的影响[J].中国中医急症,2019, 28(04):590-593+606. [23] 中国医师协会急诊医师分会,中国研究型医院学会休克与脓毒症专业委员会.中国脓毒症/脓毒性休克急诊治疗指南(2018)[J].临床急诊杂志,2018,19(09):567-588. [24] 帅佃奎,陈婷婷,吕家俊,等.传统中药血必净治疗凝血功能障碍的Meta分析[J].甘肃医药,2022,41(05):400-404. [25] 黄海兵,徐瑾.参附注射液治疗休克的临床研究[J].世界复合医学,2021,7(11):166-168+177. [26] 郭倩,刘丰进,康海,等.参附注射液对脓毒症大鼠血管内皮损伤的影响及机制[J].现代中西医结合杂志,2024,33(01):60-65. [27] 陈荣琳,曹枫,童华生,等.生脉注射液对脂多糖诱导大鼠炎症反应及血管内皮损伤的影响[J].临床急诊杂志,2016,17(08):621-624. [28] 代静静.血必净联合碳青霉烯类抗生素治疗脓毒症患者的临床疗效[J].医药前沿,2024,14(06):116-118. [29] 高慧,杨洁,胡云霞,等.清瘟败毒饮对脓毒症凝血功能障碍患者凝血指标及预后的影响[J].江苏中医药,2019,51(05):25-27.
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