刘姿含

快速冰冻切片技术是术中病理诊断的核心支撑，其应用质量直接关系手术决策科学性与患者预后。本文从标本处理规范、质量控制体系、诊断流程优化、团队协作机制及技术创新方向五个维度，系统梳理该技术应用的关键要点。通过明确标准化操作、误差防控、流程协同及技术融合等内容，为提升术中诊断准确性、时效性提供实践指导，助力精准外科手术实施与医疗质量提升。

快速冰冻切片；术中病理诊断；技术规范；质量控制；诊断准确性

[1] 魏薇.卵巢肿瘤术中冰冻切片快速病理诊断的临床价值分析[J].中国实用医药,2024,19(24):93-95. [2] 莫林,韩泽贤,欧范妍,等.术中快速冰冻病理切片检查在诊断甲状腺结节中的应用效果[J].医药前沿,2024,14(20):47-49. [3] 孟春丽.术中冰冻切片病理诊断在卵巢肿瘤中的应用价值[J].实用检验医师杂志,2024,16(01):86-88. [4] 钟全钰.术中快速冰冻乳腺肿瘤切片对病理诊断的准确性影响[J].基层医学论坛,2023,27(29):96-98+122. [5] 梁振雄.术中冰冻切片快速病理检查在诊断卵巢良恶性肿瘤中的应用[J].深圳中西医结合杂志,2021,31(09):103-105. [6] 肖欣.卵巢肿瘤术中冰冻切片的快速病理诊断结果与应用价值分析[J].中国实用医药,2023,18(07):84-87. [7] 薛佳磊,et al."早期乳腺癌术中快速冰冻切片病理学检查延迟诊断率分析:一项真实世界的回顾性研究."中国癌症杂志35.4(2025):404-411. [8] 陆子骥,储兵.乳腺癌腋窝前哨淋巴结术中冰冻与术后石蜡切片诊断结果的对照分析[J].现代医用影像学,2021,30(03):588-590. [9] Zhiling Z.Pathologic analysis of intraoperative rapid freezing and postoperative paraffin section of thyroid cancer[J].Frontiers in Medical Science Research,2023,5(7): [10] Jingping Y,Wenkang Z,Hui L,et al.Neural Network Based Classification of Breast Cancer Histopathological Image from Intraoperative Rapid Frozen Sections.[J].Journal of digital imaging,2023,36(4):1597-1607. [11] Zhe,H.A.N.,L.I.Gang,and X.U.E.Hao."The application of intraoperative molecular diagnosis in glioma surgery."Chinese Journal of Contemporary Neurology&Neurosurgery 25.3(2025). [12] Jialei,X.U.E.,et al."Predicting delayed diagnosis rate of intraoperative rapid frozen section pathological examination for early-stage breast cancer:a real-world retrospective study."China Oncology 35.4(2025):404-411.

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