缑慧瑾,武小娟

慢性阻塞性肺疾病（chronic obstructive pulmonary diseases，COPD）是以持续的不可逆性气流受限为主要特征的慢性呼吸系统疾病，慢性阻塞性肺疾病急性加重（Acute exacerbation of chronic obstructive pulmonary disease，AECOPD）是指患者的症状从通常的稳定状态急性恶化，超出正常的日常变化。AECOPD的严重程度及预后评估有较大主观性，仍需额外的动态血液生物标志物辅助。降钙素原（procalcitonin，PCT）和白蛋白（albumin，ALB）及二者比值作为重要的炎症与营养指标日益受到关注。现就PCT、ALB单独及联合检测与AECOPD的严重程度、鉴别诊断、治疗、预后相关性的研究进展进行综述，以期为AECOPD的分级及预后评估提供客观依据，有助于改善AECOPD患者的结局。

慢性阻塞性肺疾病急性加重期；降钙素原；白蛋白；预后评估；研究进展

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