李 思,张月玲

近年来，视力已成为多种疾病评估视功能的指标，但是许多疾病不能仅通过视力反映严重程度和进展，微视野可通过眼底成像和视网膜敏感度及固视率的测定形成综合检查报告，全面评估患者黄斑区视网膜功能情况，将视网膜微结构和功能相结合，客观分析二者对应关系。本文就就微视野在年龄相关性黄斑变性、黄斑前膜、黄斑裂孔、青光眼等疾病中的临床应用做一综述。

微视野；视功能；年龄相关性黄斑变性；青光眼；视网膜敏感度

[1] Timberlake G T,Mainster M A,Webb R H,et al.Retinal localization of scotomata by scanning laser ophthalmoscopy[J].1982,22. [2] Midena E,Vujosevic S,Cavarzeran F.Normal Values for Fundus Perimetry with the Microperimeter MP1[J].Ophthalmology,2010, 117(8):1571-1576.e1. [3] Seiple W,Rosen R B,Castro-Lima V,et al.The Physics and Psychophysics of Microperimetry[J].Optometry and Vision Science, 2012,89(8):1182-1191. [4] Klaver C C W.Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population:The Rotterdam Study[J]. Archives of Ophthalmology,1998,116(5):653. [5] Munk M R,Kiss C,Huf W,et al.One Year Follow-up of Functional Recovery in Neovascular AMD During Monthly Anti-VEGF Treatment[J].American Journal of Ophthalmology,2013,156(4):633-643.e2. [6] Meleth A D,Mettu P,Agrón E,et al.Changes in Retinal Sensitivity in Geographic Atrophy Progression as Measured by Microperimetry[J]. Investigative Opthalmology&Visual Science,2011,52(2):1119. [7] Holz F G,Sadda S R,Busbee B,et al.Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration:Chroma and Spectri Phase 3 Randomized Clinical Trials[J].JAMA Ophthalmology,2018,136(6):666. [8] Mitchell P,Smith W,Chey T,et al.Prevalence and Associations of Epiretinal Membranes[J].Ophthalmology,1997,104(6):1033-1040. [9] Bu S.Collagens and Retinal Müller Cells in Healthy and Diseased Vitreoretinal Interface[J]. [10] Dal Vecchio M,Lavia C,Nassisi M,et al.Microperimetric Assessment after Epiretinal Membrane Surgery:4-Year Follow-Up[J].Journal of Ophthalmology,2016,2016:1-5. [11] Sayegh R G,Georgopoulos M,Geitzenauer W,et al.High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction[J].Ophthalmology,2010,117(10):2010-2017.e2. [12] Kim J,Rhee K M,Woo S J,et al.Long-term Temporal Changes of Macular Thickness and Visual Outcome after Vitrectomy for Idiopathic Epiretinal Membrane[J].American Journal of Ophthalmology,2010,150(5):701-709.e1. [13] Massin P,Allouch C,Haouchine B,et al.Optical coherence tomography of idiopathic macular epiretinal membranes before and after surgery[J].American Journal of Ophthalmology,2000,130(6):732-739. [14] Spiteri Cornish K,Lois N,Scott N W,et al.Vitrectomy with Internal Limiting Membrane Peeling versus No Peeling for Idiopathic Full-Thickness Macular Hole[J].Ophthalmology,2014,121(3):649-655. [15] Liu Y,Yang X,Zhou W,et al.Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes[J].Photodiagnosis and Photodynamic Therapy,2025,51:104458. [16] Carvalho Araujo A C,Bordon A F,Falcão V,et al.The use of amniotic membrane or inverted internal limiting membrane flap for large or refractory macular holes:a prospective,comparative study using microperimetry[J].Graefe’s Archive for Clinical and Experimental Ophthalmology,2025. [17] Sborgia A,Boscia G,Niro A,et al.Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes[J].Frontiers in Medicine,2023,10:1276502. [18] Inooka T,Tomita R,Kominami T,et al.Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma,Classified by Severity and Misalignment of Test Points[J].Translational Vision Science&Technology,2025,14(4):6. [19] Yoshida T,Ogawa S,Miki T,et al.Evaluation of changes in retinal light sensitivity thresholds in the early postoperative days after trabeculectomy using microperimetry[J].Japanese Journal of Ophthalmology,2025,69(3):432-441. [20] Shwetar Y J,Brooks B P,Jeffrey B G,et al.Advances in machine learning for ABCA4-related retinopathy:segmentation and phenotyping[J].International Ophthalmology,2025,45(1):314. [21] Dhooge P P A,Möller P T,Boon C J F,et al.The STArgardt Remofuscin Treatment Trial(STARTT):design and baseline characteristics of enrolled Stargardt patients[version 3;peer review:2 approved][J].2022. [22] Schönbach E M,Wolfson Y,Strauss R W,et al.Macular Sensitivity Measured With Microperimetry in Stargardt Disease in the Progression of Atrophy Secondary to Stargardt Disease(ProgStar)Study:Report No.7[J].JAMA Ophthalmology,2017,135(7):696. [23] Yau J W Y,Rogers S L,Kawasaki R,et al.Global Prevalence and Major Risk Factors of Diabetic Retinopathy[J].Diabetes Care, 2012,35(3):556-564. [24] Ihsan G,Kwartika A,Widyanatha M I,et al.Early response of anti-vascular endothelial growth factor(anti-VEGF)in diabetic macular edema(DME)management:microperimetry and optical coherence tomography(OCT)findings:a pilot study at national eye center of third world country[J].BMC Ophthalmology,2024,24(1):551. [25] Gulyesil F F,Inan S,Gobeka H H,et al.Retinal ultrastructural,electrophysiological,and microvascular morphological outcomes in diabetic macular edema treated with intravitreal bevacizumab[J].Irish Journal of Medical Science(1971-),2023,192(1):149-159. [26] Stino H,Birner K,Steiner I,et al.Correlation of point-wise retinal sensitivity with localized features of diabetic macular edema using deep learning[J].Canadian Journal of Ophthalmology,2025:S0008418225000705.

点击下载PDF