罗 赛,贺 茜,宋居星私,王倩倩,张黎明

表没食子儿茶素没食子酸酯（EGCG）是绿茶中生物活性最强的儿茶素组分，但其较差的稳定性和低生物利用度限制了临床应用。纳米药物递送系统（NDDSs）为改善上述问题提供了有效途径。EGCG分子富含活性酚羟基，能通过共价或非共价作用与多种分子结合，兼具治疗潜力，因而在构建含EGCG的纳米载体方面展现出广阔前景。本文系统阐述了递送EGCG的纳米颗粒（NPs），包括聚合物、脂质体、金纳米颗粒和金属离子等，以及将EGCG本身作为功能材料，构建OEGCG、EGCG-聚合物自组装及EGCG-金属离子杂化网络等新型纳米载体的应用研究进展。

EGCG；NPs；纳米载体

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