李媛媛,袁 霞

干扰素调节因子4（IRF4）是IRF家族中具有独特生物学特性的转录因子，在免疫细胞分化、肿瘤发生及自身免疫病中发挥重要作用。近年来，随着单细胞多组学技术、基因编辑和结构生物学的突破，IRF4的功能及其在疾病中的调控机制得到深入解析。本文系统综述IRF4的结构特征、表观调控模式，及其在血液系统恶性肿瘤、自身免疫病中的最新研究进展。

IRF4；分子特性；调控机制；相关疾病研究

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