谢单宁,许资雯,卢 漫,崔文曦,李 娟

人工智能虚拟细胞（AIVC）通过集成多尺度建模将改变风湿病管理。AIVC可破译分子动力学，表示自身抗原-抗体复合物状态，模拟巨噬细胞极化等单细胞轨迹，并通过图神经网络绘制组织串扰图。它将使虚拟药物筛选能够克服耐药性，优化CAR-Treg安全性，还可构建患者特异性数字孪生体，用于预测骨侵蚀等的演变。未来，联邦学习和机器人实验或将解决数据及伦理挑战，加速风湿免疫性疾病的精准治疗。

人工智能虚拟细胞；多尺度集成；精准治疗；风湿免疫疾病

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