计维佳,简生燕

促黄体生成素（LH）是下丘脑-垂体-卵巢轴（HPOA）的关键调节激素，在女性生殖内分泌生理与病理中起核心作用，由腺垂体合成分泌，通过结合靶器官受体调控甾体激素合成及卵泡发育。多囊卵巢综合征（PCOS）患者LH升高及比值失调引发雄激素过多等问题；中枢性性早熟（CPP）因下丘脑GnRH激活过早致LH脉冲异常，加速性发育；内分泌性不孕症中，排卵障碍与LH分泌紊乱相关，黄体功能不全也与LH脉冲异常有关。本文探究LH与上述疾病的关联机制，为揭示发病机制及优化诊疗提供理论支撑。

促黄体生成素；中枢性早熟；PCOS；排卵障碍；黄体功能不全

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