陈媛媛,于显博,吴泽璇

子宫内膜息肉是妇科常见的子宫内膜良性病变，由子宫内膜腺体、间质和血管组成，表现为子宫腔内突出的赘生物。尽管多数息肉为良性，但仍存在恶变风险，尤其是绝经前后女性，其恶变概率相对较高，严重威胁患者健康。近年来，关于绝经前后子宫内膜息肉恶变危险因素的研究逐渐深入，本文将对相关研究进展进行综述。

子宫内膜息肉绝经恶变危险因素

[1] 姜伶俐,吴方跃.子宫内膜息肉的临床研究进展[J].中国当代医药,2018,25(28):29-31+35. [2] 张颖,王颖梅.子宫内膜息肉恶变诊治专家指导意见(2022年版)[J].中国实用妇科与产科杂志,2022,38(05):529-533. [3] BAJRACHARYA N.子宫内膜息肉的发病因素研究[D],2015. [4] QIU R,ZHONG Y,HU M,et al.Breastfeeding and Reduced Risk of Breast Cancer:A Systematic Review and Meta-Analysis[J].Comput Math Methods Med,2022,2022:8500910. [5] Min S,Wenjing Z.Predictive factors of endometrial lesions in patients with abnormal uterine bleeding.[J].European journal of obstetrics,gynecology,and reproductive biology,2023,28867-72. [6] 李丽,李娜,薛九霞.围绝经期异常子宫出血合并子宫内膜病变的相关危险因素分析[J].青海医药杂志,2025,55(05):7-10. [7] 关诗敏.绝经后子宫内膜病变相关因素的临床分析[D].吉林大学,2024. [8] 王露.绝经后出血患者子宫内膜厚度､雌激素水平的临床研究[D].湖北医药学院,2024. [9] 张蜀苏.子宫内膜不典型增生术后病理升级为癌的危险因素分析[D].新疆医科大学,2024. [10] Yang Y,Zhou J,Lv Q,et al.Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells[J].Frontiers in Pharmacology,2025,161573032-1573032. [11] Paravidine M L S,Cordeiro R K A,Godoy M C A F,et al.Factors Associated with Malignancy in Hysteroscopically Resected Endometrial Polyps:A Systematic Review and Meta-Analysis[J].The Journal of Minimally Invasive Gynecology,2017, [12] Vasilios P,Anastasia P,Charalampos S,et al.Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps:a meta-analysis of observational studies.[J].Menopause(New York,N.Y.),2016,23(6):691-7. [13] Committee Opinion No.601:Tamoxifen and uterine cancer.[J].Obstetrics and gynecology,2014,123(6):1394-7. [14] 程星翰,杨隽钧,向阳.晚期和复发子宫内膜癌靶向及免疫治疗的应用进展[J].实用妇产科杂志,2025,41(04):279-282.

点击下载PDF