作者
鲍润岩,龚 伟,姜峣璐,戎瑞雪
文章摘要
萘酰亚胺类化合物因其良好的荧光特性和抗肿瘤活性,被广泛应用于细胞成像研究以及抗肿瘤药物研究中。本文系统综述了萘酰亚胺的荧光特性与抗肿瘤机制,并探讨了糖类分子在肿瘤靶向中的作用。进一步,结合萘酰亚胺的荧光特性、抗肿瘤活性以及糖修饰后的靶向能力,讨论了二者结合后在细胞器或肿瘤细胞靶向中的应用前景。
文章关键词
萘酰亚胺;荧光探针;抗肿瘤;糖靶向
参考文献
[1] SCOTT E,ELLIOTT D J,MUNKLEY J.Tumour associated glycans:A route to boost immunotherapy[J].Clinica Chimica Acta; International Journal of Clinical Chemistry,2020,502:167-173.
[2] XU J,WANG C,MA Q,et al.Novel Mitochondria-Targeting and Naphthalimide-based Fluorescent Probe for Detecting HClO in Living Cells[J].ACS Omega.2021;6(22):14399-14409.
[3] LIANG X,ZHANG L,XU X,et al.An ICT-Based Mitochondria-Targeted Fluorescent Probe for Hydrogen Peroxide with a Large Turn-On Fluorescence Signal[J].Chemistryselect,2019,4:1330-1336.
[4] ZHOU R,PENG Q,WAN D,et al.Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model[J].RSC advances,2021,11(39):24032-24037.
[5] RONG RX,WANG SS,LIU X,et al.Lysosomes-targeting imaging and anticancer properties of novel bis-naphthalimide derivatives. Bioorg Med Chem Lett.2018,28(4):742-747.
[6] FENG X C,ZHANG G,SUN R,et al.Golgi polarity fluorescent imaging based on coumarin or 1,8-naphthalimide derivatives in three channels[J/OL].Sensors and Actuators B:Chemical,2023,394:134469.
[7] LIU SZ,XU JH,MA QJ,et al.A naphthalimide-based and Golgi-targetable fluorescence probe for quantifying hypochlorous acid. Spectrochim Acta A Mol Biomol Spectrosc.2023,286:121986.
[8] LEE Y C,CHIOU J T,WANG L J,et al.Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway[J].Toxicology and Applied Pharmacology,2023,474:116625.
[9] SAURABH GUPTA,KAMALDEEP PAUL.DNA damage and intercalation by elinafide modified bis-naphthalimides for their anticancer activity[J].Journal of Molecular Liquids,2023,382:121980.
[10] TUNG C H,LU Y T,KAO W T,et al.Discovery of a more potent anticancer agent than C4-benzazole 1,8-naphthalimide derivatives against murine melanoma[J].Journal of The Chinese Chemical Society,2020,67(7):1254-1262.
[11] LIANG G B,WEI J H,JIANG H,et al.Design,synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA[J].European Journal of Medicinal Chemistry,2021,210:112951.
[12] XIN M,WEI J H,YANG C H,et al.Design,synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents[J].Bioorganic&Medicinal Chemistry Letters,2020,30(8):127051.
[13] XU X,GE C,WANG S,et al.Polyamine-modified naphthalimide derivative 9C inhibits colorectal cancer through ROS-mediated ER stress,migration and invasion[J].Toxicology in Vitro:An International Journal Published in Association with BIBRA,2025,103:105974.
[14] LIANG Q,ZHANG S,LIU J,et al.Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer[J].Bioorganic Chemistry,2024,150:107596.
[15]QIU,Y,XIE,E,DU,J,et al.Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity[J].2024,Cancer Cell.
[16] ZHANG W.,CHENG H.,Gui Y.,et al.Mannose treatment:A promising novel strategy to suppress inflammation[J].Frontiers in Immunology,2021,12:756920.
[17] ZHANG X,JIANG Y,CHEN H,et al.GLUT1 as a Potential Target for Cancer Therapy[J].International Journal of Molecular Sciences, 2022,23(10):5444.
[18] BRASÓ-MARISTANY F,FERRERO-CAFIERO JM,FALATO C,et al.Patritumab deruxtecan in HER2-negative breast cancer:part B results of the window-of-opportunity SOLTI-1805 TOT-HER3 trial and biological determinants of early response.Nat Commun.2024;15(1):5826.
[19] LU SU,YINGLE FENG,KONGCHANG WEI,et al.Chemical Reviews 2021,121(18),10950-11029.
[20] GOPALA L,CHA Y,LEE MH.Versatile naphthalimides:Their optical and biological behavior and applications from sensing to therapeutic purposes[J].Dyes and Pigments,2022,208:110195.
Full Text:
DOI