杜宝荣,郭新建,郑小影,韩志平,赵吉萍

锌指环指蛋白3（ZNRF3）是一种重要的跨膜E3泛素连接酶，在Wnt信号通路中发挥关键的负调节作用，近年来其在肿瘤发生与发展中的研究逐渐增多。ZNRF3通过调节Wnt受体降解直接影响细胞的增殖、分化及干性维持，其表达异常、基因突变及表观遗传修饰与多种肿瘤的预后密切相关。本文旨在系统综述ZNRF3在不同肿瘤类型中的表达特征、分子机制及其与肿瘤免疫微环境的相互作用，探讨ZNRF3作为肿瘤预后标志物和治疗靶点的潜在应用价值，以期为肿瘤的精准诊疗提供新的理论依据。

锌指环指蛋白3（ZNRF3）；肿瘤；Wnt信号通路；E3泛素连接酶；生物标志物

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