苏振兰,郭新建

DCAF（DDB1-CUL4-associated factor）蛋白家族作为CRL4泛素连接酶复合物的关键底物识别亚基，通过介导靶蛋白的特异性泛素化修饰，广泛参与细胞周期调控、DNA损伤修复、信号转导及基因表达等关键生物学过程。近年研究表明，多种DCAF成员在肿瘤中呈现异常表达，并通过失调的泛素化降解途径驱动肿瘤发生、进展及治疗抵抗。本综述系统梳理了DCAF家族核心成员（如DCAF1、DCAF2、DCAF7、DCAF8、DCAF12、DCAF13等）在肝癌、结直肠癌、胃癌、多发性骨髓瘤等恶性肿瘤中的表达特征、分子机制及临床意义，探讨其作为新型诊断标志物和治疗靶点的潜力，并展望该领域面临的挑战与未来研究方向。

DCAF；肿瘤；分子机制；临床意义

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