于 弋,张 媚,卢 谦

心血管疾病（Cardiovascular disease，CVD）一直是威胁全世界人群生命健康的疾病之一，在中国，CVD占疾病的死亡构成比同样位居首位，尽管目前随着医疗水平的发展，心血管疾病的预防和治疗都得到了很大的改善，但人口老龄化及不健康的生活习惯等，我国CVD的患病率及死亡率仍在逐年升高，近年来随着对CVD的研究进展，发现炎症机制在CVD中发挥着举足轻重的作用，研究表明，白细胞衍生物SII等新型炎症指标在众多心血管疾病的预防、治疗及预后等多方面有着重要的作用，可能成为评估心血管疾病的一个重要指标。本文就近几年来有关系统免疫炎症指数对心血管疾病的研究进展有关文献综述如下。

系统免疫炎症反应；炎症反应；心血管疾病；研究进展

[1] 刘明波,何新叶,杨晓红,等.《中国心血管健康与疾病报告2023》要点解读[J].中国心血管杂志,2024,29(04):305-324. [2] 匙亮.《中国卫生健康发展评价报告(2022)》蓝皮书在威发布[N].威海日报,2023-04-16. [3] 陶斯阳,马晶茹.代谢性炎症与冠心病发病机制研究的进展[J].沈阳医学院学报,2023,25(04):337-340. [4] Hu B,Yang X R,Xu Y,et al.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma[J].Clin Cancer Res,2014,20(23):6212-6222. [5] Nost T H,Alcala K,Urbarova I,et al.Systemic inflammation markers and cancer incidence in the UK Biobank[J].Eur J Epidemiol, 2021,36(8):841-848. [6] Li X,Cui L,Xu H.Association between systemic inflammation response index and chronic kidney disease:a population-based study[J]. Front Endocrinol(Lausanne),2024,15:1329256. [7] Wang L,Qin X,Zhang Y,et al.The prognostic predictive value of systemic immune index and systemic inflammatory response index in nasopharyngeal carcinoma:A systematic review and meta-analysis[J].Front Oncol,2023,13:1006233. [8] Ma R,Cui L,Cai J,et al.Association between systemic immune inflammation index,systemic inflammation response index and adult psoriasis:evidence from NHANES[J].Front Immunol,2024,15:1323174. [9] Wolf D,Ley K.Immunity and Inflammation in Atherosclerosis[J].Circ Res,2019,124(2):315-327. [10] 马依彤,李洋.血细胞参数在冠心病发生、发展过程中作用的研究进展[J].新疆医科大学学报,2020,43(02):145-148. [11] 巨名飞,董文超,于健,等.血常规中炎症指数与老年ACS患者冠状动脉狭窄严重程度的相关性[J].中国老年学杂志,2023,43(09):2060-2063. [12] Madjid M,Awan I,Willerson J T,et al.Leukocyte count and coronary heart disease:implications for risk assessment[J].J Am Coll Cardiol,2004,44(10):1945-1956. [13] Li H,Shen C,Chen B,et al.Interleukin‑37 is increased in peripheral blood mononuclear cells of coronary heart disease patients and inhibits the inflammatory reaction[J].Mol Med Rep,2020,21(1):151-160. [14] Madjid M,Fatemi O.Components of the complete blood count as risk predictors for coronary heart disease:in-depth review and update[J].Tex Heart Inst J,2013,40(1):17-29. [15] 张世袍,杨阳,陈才鸿,等.系统免疫炎症指数、心外膜脂肪厚度与冠状动脉病变严重程度的相关性分析[J].医学理论与实践, 2024,37(14):2445-2447. [16] Dziedzic E A,Gasior J S,Tuzimek A,et al.Blood Count-Derived Inflammatory Markers and Acute Complications of Ischemic Heart Disease in Elderly Women[J].J Clin Med,2023,12(4). [17] Li Q,Ma X,Shao Q,et al.Prognostic Impact of Multiple Lymphocyte-Based Inflammatory Indices in Acute Coronary Syndrome Patients[J].Front Cardiovasc Med,2022,9:811790. [18] Boulet J,Sridhar V S,Bouabdallaoui N,et al.Inflammation in heart failure:pathophysiology and therapeutic strategies[J].Inflamm Res, 2024,73(5):709-723. [19] Daou D,Gillette T G,Hill J A.Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction[J].Physiology(Bethesda), 2023,38(5):0. [20] Charach G,Grosskopf I,Roth A,et al.Usefulness of total lymphocyte count as predictor of outcome in patients with chronic heart failure[J].Am J Cardiol,2011,107(9):1353-1356. [21] Strassheim D,Dempsey E C,Gerasimovskaya E,et al.Role of Inflammatory Cell Subtypes in Heart Failure[J].J Immunol Res, 2019,2019:2164017. [22] He Z,Gao B,Deng Y,et al.Associations between systemic immune-inflammation index and heart failure:A cross-sectional study[J]. Medicine(Baltimore),2024,103(42):e40096. [23] Balci K,Erbay I,Demirkan B,et al.The association of hemodynamic markers of right ventricular dysfunction with SII index and clinical outcomes in reduced ejection fraction heart failure[J].Medicine(Baltimore),2023,102(34):e34809. [24] Wang Z,Qin Z,Yuan R,et al.Systemic immune-inflammation index as a prognostic marker for advanced chronic heart failure with renal dysfunction[J].ESC Heart Fail,2023,10(1):478-491. [25] 鹿畅,陈中元,王经元,等.血清BNP、SII、TyG与急性心肌梗死合并2型糖尿病患者急诊PCI术后主要不良心血管事件的关系分析[J].现代生物医学进展,2024,24(17):3294-3299. [26] Tang Y,Zeng X,Feng Y,et al.Association of Systemic Immune-Inflammation Index With Short-Term Mortality of Congestive Heart Failure:A Retrospective Cohort Study[J].Front Cardiovasc Med,2021,8:753133. [27] 中华人民共和国国家卫生健康委员会.成人高血压食养指南（2023年版）[J].全科医学临床与教育,2023,21(06):484-485. [28] 杨翔宇,张鑫,陈晓平.2023版欧洲高血压学会动脉高血压管理指南的更新要点解读[J].中华高血压杂志(中英文),2024, 32(02):112-114. [29] Zhang Z,Zhao L,Zhou X,et al.Role of inflammation,immunity,and oxidative stress in hypertension:New insights and potential therapeutic targets[J].Front Immunol,2022,13:1098725. [30] Deussen A,Kopaliani I.Targeting inflammation in hypertension[J].Curr Opin Nephrol Hypertens,2023,32(2):111-117. [31] Hengel F E,Benitah J P,Wenzel U O.Mosaic theory revised:inflammation and salt play central roles in arterial hypertension[J].Cell Mol Immunol,2022,19(5):561-576. [32] Jin N,Huang L,Hong J,et al.The association between systemic inflammation markers and the prevalence of hypertension[J].BMC Cardiovasc Disord,2023,23(1):615. [33] Zheng Y,Zhong D,Li J,et al.Systemic immune-inflammation index and long-term mortality in patients with hypertension:a cohort study[J].J Hypertens,2025,43(3):464-473. [34] 刘川,马丽娜,曹若瑾,等.系统性免疫炎性指数、动态动脉硬化指数与老年原发性高血压患者左心室肥大的关系[J].疑难病杂志, 2025,24(06):651-655. [35] Karayigit O,Nurkoc S G,Celik M C.Systemic immune-inflammation index(SII)may be an effective indicator in predicting the left ventricular hypertrophy for patients diagnosed with hypertension[J].J Hum Hypertens,2023,37(5):379-385. [36] Zhang Y,Wang Y T,Shan Z L,et al.Role of inflammation in the initiation and maintenance of atrial fibrillation and the protective effect of atorvastatin in a goat model of aseptic pericarditis[J].Mol Med Rep,2015,11(4):2615-2623. [37] Naser A,Sayilan S,Guven O,et al.Inflammation Burden and Atrial Fibrillation Burden:A Bidirectional Relationship[J].Arq Bras Cardiol,2024,121(6):e20230680. [38] Scott L J,Li N,Dobrev D.Role of inflammatory signaling in atrial fibrillation[J].Int J Cardiol,2019,287:195-200. [39] Dobrev D,Heijman J,Hiram R,et al.Inflammatory signalling in atrial cardiomyocytes:a novel unifying principle in atrial fibrillation pathophysiology[J].Nat Rev Cardiol,2023,20(3):145-167. [40] Yao C,Veleva T,Scott L J,et al.Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation[J].Circulation, 2018,138(20):2227-2242. [41] Omur S E,Zorlu C,Yilmaz M.Comparison of the Relationship Between Inflammatory Markers and Atrial Fibrillation Burden[J].Anatol J Cardiol,2023,27(8):486-493. [42] Wang Y J,Liu K S,Meng X J,et al.Role of a new inflammation predictor in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation[J].World J Cardiol,2024,16(12):740-750. [43] Kaplan E,Ekizler F A,Saribas H,et al.Effectiveness of the systemic immune inflammation index to predict atrial fibrillation recurrence after cryoablation[J].Biomark Med,2023,17(2):101-109. [44] 王越,郑汝杰,袁明月,等.系统性免疫炎症指数对老年心房颤动患者预后价值的研究[J].中华老年心脑血管病杂志, 2022,24(02):136-139.

点击下载PDF