作者
马依努尔·吾斯曼,古丽斯坦·库尔班,王继萍,余 刚
文章摘要
肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)是我国5岁及以上儿童最主要的社区获得性肺炎,病情重者易发生肺外并发症,最常见为皮肤黏膜损害,甚至出现反应性感染性皮肤黏膜疹(Reactive Infectious Mucocutaneous Eruption,RIME)。本研究回顾性分析阿克苏地区第一人民医院儿科收治的3例MPP并发RIME患儿的临床资料及治疗经过,结合国内外近年来的文献报道,探讨其临床特点,并总结诊治经验。
文章关键词
肺炎支原体肺炎;反应性感染性皮肤黏膜疹;病例分析
参考文献
[1] Lofgren D,Lenkeit C.Mycoplasma Pneumoniae-Induced Rash and Mucositis:A Systematic Review of the Literature[J].Spartan Med Res J,2021,6(2).
[2] Rochelle T,Malika L,Nicole J,et al.Reactive infectious mucocutaneous eruption-repeat etanercept after intravenous immunoglobulin:A case report.[J].SAGE Open Med Case Rep,2022,10(0).
[3] Canavan T N M,Mathes E F M,Frieden I M,et al.Mycoplasma pneumoniae–induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme:A systematic review[J].J Am Acad Dermatol,2015,72(2):239-245.
[4] Amode R,Ingen-Housz-Oro S,Ortonne N,et al.Clinical and histologic features of Mycoplasma pneumoniae–related erythema multiforme:A single-center series of 33 cases compared with 100 cases induced by other causes[J].J Am Acad Dermatol,2018, 79(1):110-117.
[5] Watkins L,Olson D,Diaz M H,et al.Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M.pneumoniae-associated Stevens-Johnson Syndrome[J].Pediatr Infect Dis J,2017,36(6):564-571.
[6] Prindaville B,Newell B D,Nopper A J,et al.Mycoplasma pneumonia--associated mucocutaneous disease in children:dilemmas in classification[J].Pediatr dermatol,2014,31(6):670-675.
[7] 魏二虎,方敩,靳培娜,等.儿童肺炎支原体感染致多形红斑3例[J].中华实用儿科临床杂志,2020,35(20):1583-1585.
[8] Gise R,Elhusseiny A M,Scelfo C,et al.Mycoplasma Pneumoniae-Induced Rash and Mucositis:A Longitudinal Perspective and Proposed Management Criteria[J].Am J Ophthalmol,2020,219:351-356.
[9] Kohanim S,Palioura S,Saeed H N,et al.Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis-A Comprehensive Review and Guide to Therapy.II.Ophthalmic Disease[J].Ocul Surf,2016,14(2):168-188.
[10] Li H O,Colantonio S,Ramien M L.Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine[J].J Cutan Med Surg,2019,23(6):608-612.
[11] Miller M M,Kamath S,Hughes M,et al.Evaluation of Etanercept for Treatment of Reactive Infectious Mucocutaneous Eruption[J]. JAMA dermatology(Chicago,Ill.),2021,157(2):230-232.
[12] 国家卫生健康委.儿童肺炎支原体肺炎诊疗指南(2023年版)[Z].2023.
[13] Campagna C,Tassinari D,Neri I,et al.Mycoplasma pneumoniae-induced recurrent Stevens-Johnson syndrome in children:a case report[J].Pediatr Dermatol,2013,30(5):624-626.
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