梁 华,江国英

目的：探讨雷公藤内酯醇（TP）通过调控miR-7及PTEN/PI3K/Akt通路促进系统性红斑狼疮（SLE）B细胞凋亡的分子机制，为SLE治疗提供理论依据。方法：基于Web of Science及中国知网数据库检索2004-2025年相关文献，结合分子生物学实验假设，分析TP对miR-7、PTEN/PI3K/Akt通路及B细胞凋亡的调控关系，并总结现有研究进展与争议点。结论：TP可能通过上调miR-7抑制PTEN表达，间接激活PI3K/Akt通路，诱导SLE B细胞凋亡；miR-7在SLE中呈现异常高表达，其与PTEN的靶向关系形成"负负得正"的调控网络。讨论：TP调控miR-7的具体机制及通路异质性需进一步验证，未来需结合单细胞测序与临床队列研究明确其亚型特异性及转化潜力。

雷公藤内酯醇；miR-7；PTEN/PI3K/Akt通路；系统性红斑狼疮

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