彭 盼,范培云

多项研究表明，肥胖是2型糖尿病患者合并甲状腺结节的常见危险因素，且肥胖已成为严重影响国人身体健康的慢性致残因素，为了更好的了解肥胖对2型糖尿病合并甲状腺结节的影响机制，本文对此做一综述。

肥胖；2型糖尿病；甲状腺结节

[1] 王佳仪.《肥胖症诊疗指南》:从纸上走向实践[N].中国食品报,2024-12-04(003). [2] Powell-Wiley T M,Poirier P,Burke L E,et al.Obesity and Cardiovascular Disease:A Scientific Statement From the American Heart Association[J].Circulation,2021,143(21):CIR0000000000000973-. [3] 中国2型糖尿病防治指南(2020年版)(上)[J].中国实用内科杂志,2021,41(08):668-695. [4] Cooper D,Doherty G,Haugen B,et al.Differentiated Thyroid C,Cooper DS,Doherty GM,Haugen BR,Kloos RT,Lee SL,Mandel SJ,Mazzaferri EL,McIver B,Pacini F,Schlumberger M,Sherman SI,Steward DL,Tuttle RM:revised American Thyroid Association management guidelines for patients with thyr[J].2009 [5] 李玉姝,单忠艳,滕卫平.《甲状腺结节和分化型甲状腺癌诊治指南(第二版)》解读[J].中国实用内科杂志,2023,43(11):884-889. [6] Buscemi S,Massenti F M,Vasto S,et al.Association of obesity and diabetes with thyroid nodules[J].Endocrine,2017. [7] Yang H X,Zhong Y,Lv W H,et al.Association of adiposity with thyroid nodules:a cross-sectional study of a healthy population in Beijing,China[J].BMC Endocrine Disorders,2019,19(1). [8] 刘玉敏.饮食连续护理对2型糖尿病合并肥胖症患者护理质量及睡眠的影响效果分析[J].世界睡眠医学杂志,2020,7(04):662-664. [9] Ellulu M S,Ismail P,Khaza’ai Huzwah,et al.Obesity and inflammation:the linking mechanism and the complications[J].Archives of Medical Science Ams,2017,13:851-863. [10] American Diabetes Association.2.Classification and Diagnosis of Diabetes:Standards of Medical Care in Diabetes-2019.Diabetes Care.2019 Jan;42(Suppl 1):S13-S28. [11] Ahmadi S,Pappa T,Kang A,et al.Point of Care Measurement of Body Mass Index and Thyroid Nodule Malignancy Risk Assessment[J].Frontiers in Endocrinology,2022,13. [12] Siqueira R A D,Rodrigues A P D S,Miamae L M,et al.Thyroid Nodules in Severely Obese Patients:Frequency and Risk of Malignancy on Ultrasonography[J].Endocrine Research[2025-05-15]. [13] 张晶镔,肖越,于浩,等.甲状腺功能正常2型糖尿病患者发生甲状腺结节危险因素分析[J].临床军医杂志,2022,50(03):257-260. [14] Rosen E,Spiegelman B.What We Talk About When We Talk About Fat[J].Cell,2014,156(1-2):20-44. [15] Cndido A P C,Geloneze B,Calixto A,et al.Adiponectin,HOMA-Adiponectin,HOMA-IR in Children and Adolescents:Ouro Preto Study[J].Indian journal of pediatrics,2021,88(4):336-344. [16] AYA,ASK,ANO,et al.Paradoxical Decrease of an Adipose-Specific Protein,Adiponectin,in Obesity-ScienceDirect[J].Biochemical and Biophysical Research Communications,1999,257(1):79-83. [17] 齐天莹,张汝轩,周新丽.2型糖尿病与甲状腺结节关系的研究进展[J].老年医学研究,2024,5(03):69-73. [18] Townsend L K,Steinberg G R.AMPK and the Endocrine Control of Metabolism[J].Endocrine Reviews,2023(5):5. [19] 冯明,陈素芳,李天艺.脂联素､瘦素､Pref-1与胰岛素抵抗关系及联合检测预测糖尿病前期病情进展风险的效能[J].海南医学, 2024,35(16):2295-2300. [20] Clémence Blouet,Ono H,Schwartz G J.Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis[J]. Cell Metabolism,2008,8(6):459-467. [21] Cignarelli A,Genchi VA,Perrini S,Natalicchio A,Laviola L,Giorgino F.Insulin and Insulin Receptors in Adipose Tissue Development. Int J Mol Sci.2019 Feb 11;20(3):759. [22] 李圆园,谷昭艳,李翔,等.老年男性2型糖尿病患者合并甲状腺结节影响因素分析[J].中华保健医学杂志,2020,22(01):5-8. [23] Kun W,Yu Y,Yang W,et al.The association between insulin resistance and vascularization of thyroid nodules.[J].Journal of Clinical Endocrinology&Metabolism,2015(1):184-92. [24] 黄丽,潘佳玥,杨杨.IGF-1在2型糖尿病及2型糖尿病肾病中的作用机制研究进展[J].疑难病杂志,2024,23(02):253-256. [25] 陈素芳,李华,冯明,等.中老年2型糖尿病患者甲状腺结节患病情况分析[J].中华老年医学杂志,2012,31(008):653-656. [26] Shi Z,Pelletier N E,Wong J,et al.Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus[J].2020. [27] Xiang Y,Xu Y,Bhandari A,et al.Serum TSH levels are associated with postoperative recurrence and lymph node metastasis of papillary thyroid carcinoma[J].American journal of translational research,2021,13(6):6108-6116. [28] 何志坚,谭羽灿,徐国建,等.甲状腺结节发病原因多因素研究分析[J].岭南现代临床外科,2019,19(05):555-558+562. [29] Guo S.Insulin signaling,resistance,and the metabolic syndrome:insights from mouse models into disease mechanisms[J].Journal of Endocrinology,2013. [30] Manami I,Motoki I,Tetsuya O,et al.Diabetes Mellitus and the Risk of Cancer:Results From a Large-Scale Population-Based Cohort Study in Japan[J].Archives of Internal Medicine,2006,166(17):1871. [31] Meng L H,Chen C H,Liu Y,et al.Epidemiological survey of the status of iodine nutrition and thyroid diseases in Guangxi, China[J].Journal of Trace Elements in Medicine and Biology,2022,70:126918-. [32] Andersson M,Braegger C P.The Role of Iodine for Thyroid Function in Lactating Women and Infants(vol 43,pg 469,2022)[J]. Endocrine Reviews,2022(3):43. [33] Nikitski A V,Condello V,Divakaran S S,et al.Inhibition of ALK-Signaling Overcomes STRN-ALK-Induced Downregulation of the Sodium Iodine Symporter and Restores Radioiodine Uptake in Thyroid Cells.[J].Thyroid:official journal of the American Thyroid Association,2022. [34] 张倩为,綦一澄,汤明明,等.碘与甲状腺疾病的研究进展[J].医学综述,2021,27(07):1373-1379.

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