黄 靖,吴海东

脓毒症被定义为由宿主对感染的反应失调并导致器官功能障碍的临床综合征。在脓毒症中，急性呼吸窘迫综合征是最常见的脓毒症相关的器官功能障碍之一。在急危重症患者中，脓毒症相关急性呼吸窘迫综合征（Acute Respiratory Distress Syndrome，ARDS）发生迅速，并将明显增加院内死亡风险。脓毒症相关的ARDS发病机制与细胞死亡、内皮细胞损伤、线粒体功能障碍、氧化应激等过程相关，但尚未完全明确。与此同时基于上述发病机制，目前已经提出了抗感染、呼吸支持治疗、间充质干细胞疗法、线粒体复苏疗法、内皮糖萼修复等脓毒症相关ARDS的治疗方法，本文对脓毒症相关的ARDS的发病机制、高危因素、治疗方式进行综述。

脓毒症；急性呼吸窘迫综合征；发病机制；治疗策略

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