廖 巍,黄炳臣

目的：探讨结直肠癌中MCT4、GLUT4蛋白的表达及临床意义。方法：采用免疫组织化学染色EnVision两步法检测MCT4及GLUT4蛋白在109例结直肠癌及癌旁组织中的表达情况，分析蛋白表达水平与CRC患者临床病理特征的关系。结果：MCT4和GLUT4在CRC组织中表达水平均高于癌旁组织（P＜0.05），MCT4蛋白在男性患者癌组织中的表达明显高于女性患者的表达（P＜0.05），MCT4蛋白的表达与患者年龄、T分期、淋巴结转移、肿瘤发生部位及分化程度均无明显相关性（P＞0.05）；GLTU4蛋白在女性患者癌组织中的表达显著高于男性患者的表达，且GLUT4的高表达与CRC的淋巴结转移相关（P＜0.05），而与患者年龄、T分期、肿瘤发生部位及分化程度均无明显相关性（P＞0.05）。结论：MCT4和GLUT4参与结直肠癌的发生发展并发挥促癌基因样作用，两者在CRC中的表达无相互协调作用，MCT4和GLUT4的表达可能与CRC的性别二态性有关，联合检测两者对CRC的诊断、治疗及预后判断具有重要意义。

结直肠癌；MCT4；GLUT4；临床病理特征

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