陈道苏,李英兰

慢性阻塞性肺疾病急性加重期（Acute Exacerbation of Chronic Obstructive Pulmonary Disease，AECOPD）作为疾病发生发展过程中的关键时期，其主要特点是呼吸道症状急性加重，临床症状和体征变化显著超出日常波动范围，导致药物治疗方案调整，进而增加AECOPD发病频率和患者死亡风险。已有相关研究表明，5-羟色胺（5-hydroxytyptamine，5-HT）在AECOPD病程进展中发挥着重要的作用：首先，5-HT通过激活炎症信号通路刺激COPD患者的炎症反应，同时促进气道平滑肌收缩加重COPD患者气流受限程度，还与肺动脉高压的形成有关；其次，5-HT还能作为潜在的预后生物标志物和治疗靶点；最后，5-HT转运体（Serotonin Transporter，SERT）基因的多态性变异也被证实能够影响个体对COPD的易感性。综上所述，5-HT对AECOPD的影响是多方面的，但是其具体机制未完全阐明，还需进一步的深入探索。

慢性阻塞性肺疾病；急性加重期；5-羟色胺；炎症反应

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