杨 黎,刘 冀

随着医学科学技术迅猛发展，人体脂肪分布及各部位脂肪含量测定方式日渐丰富，脂肪定量评价愈发精准。腹部脂肪沉积及脂代谢紊乱是胰岛素抵抗（Insulin resistance，IR）的重要发病因素之一，胰岛素抵抗又是2型糖尿病（T2DM）发生发展的重要病理生理机制。有研究显示，内脏肥胖人群代谢性疾病发病风险显著增加，内脏脂肪面积可能在胰岛素抵抗与T2DM发病中起重要作用。近来研究表明，海拔与糖尿病、肥胖的发生率间存在一定相关关系，可能通过影响代谢和脂肪分布来调节这一关系。故量化评价腹部脂肪与胰岛素抵抗和T2DM的相关性，探讨不同海拔地区T2DM患者腹部脂肪量化评价相关性研究进展，对腹型肥胖或正常体重代谢性肥胖患者在T2DM预防、早期诊断及个性化治疗方面意义重大。

腹部脂肪；内脏脂肪面积；肥胖；海拔；2型糖尿病；胰岛素抵抗

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