孙 逊,杨青岩

类风湿性关节炎（RA）是一种自身免疫性疾病，其炎症过程涉及骨骼系统，不仅引起滑膜炎症和局部、关节旁的骨侵蚀，还会导致全身性的骨质流失，继发性骨质疏松（OP）；RA患者的OP风险明显高于健康人群，且股骨、脊柱等部位的骨折风险增加，严重影响了RA患者的预后和生存质量；RA合并OP突出了免疫系统和骨骼系统之间的联系，本综述将以骨免疫学的观点为基础，以免疫系统细胞与骨重塑细胞的相互作用为方向，从细胞信号传导通路、细胞因子、自身抗体等方面讨论RA合并OP的发病机制，并描述它们之间存在的相互关系，为潜在的临床治疗提供理论依据。

类风湿关节炎；骨质疏松症；发病机制

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