钱 超,陈国俊

膀胱癌的治疗依赖于多学科综合治疗策略，包括手术、化疗、免疫疗法和靶向治疗等。通过整合多种治疗方法，能够在提高治愈率的同时减少疾病复发和转移的风险。本研究分析了当前多学科综合治疗在膀胱癌中的应用效果，探讨了各个治疗手段之间的协同作用以及实际效果。研究表明，综合治疗策略对改善患者预后具有显著作用，但在临床实践中仍面临一定的挑战与不足。

膀胱癌；多学科治疗；免疫疗法；靶向治疗；预后

[1] Chen X,Diao W,Guo X,et al.The N6-methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression.[J].The FEBS journal,2025. [2] 汪红姣,张丽,王颖,等.共享决策在膀胱癌患者中的研究进展[J].护理学杂志,2023,38(07):121-124. [3] Niu S,Huang S,Shi M,et al.Discovery of new aphidicolin diterpenoids from the deep-sea-derived fungus Botryotinia fuckeliana with cytotoxic activity against human bladder cancer cells[J].Bioorganic Chemistry,2025,157108311-108311. [4] 阿力木·罗合曼,郑岩,王晶莹,等.ARPC3在膀胱癌患者尿液中的表达及意义[J].中国实验诊断学,2025,29(03):345-348. [5] Cheng M,Zhang L,Han X,et al.High-fidelity telomerase activity assay based on light-triggered nucleic acid separation system for the diagnosis of bladder cancer[J].Biosensors and Bioelectronics,2025,278117355-117355. [6] Dai L,Ye K,Yao G,et al.Using machine learning for predicting cancer-specific mortality in bladder cancer patients undergoing radical cystectomy:a SEER-based study[J].BMC Cancer,2025,25(1):523-523. [7] 李承钰,李瑜,魏广金,等.膀胱癌组织中MCP-1､VEGF表达及其临床意义[J].实用癌症杂志,2025,40(03):373-375. [8] 井丽,许翠萍,赵军燕,等.1例膀胱癌患者应用替雷利珠单抗致免疫重叠综合征的护理[J].当代护士(上旬刊),2025,32(03):102-105. [9] Cai L,Yang X,Yu J,et al.Deep learning on T2WI to predict the muscle-invasive bladder cancer:a multi-center clinical study[J].Scientific Reports,2025,15(1):9942-9942. [10] 李雅舒,卢焱,顾有为,等.膀胱癌线粒体SLC25的研究进展[J].吉林医学,2025,46(01):186-192. [11] Ahanidi E H,Azzouzi E M,Addoum B,et al.STAT1 and STAT4 expression as prognostic biomarkers in patients with bladder cancer.[J].Molecular and clinical oncology,2025,22(4):33. [12] 袁媛,朱玲玲,胡月,等.应用多学科诊疗提高肌层浸润性膀胱癌根治性手术术后患者生存质量的研究[J].新疆医科大学学报, 2021,44(12):1364-1368. [13] Pérez M,Lozano J J,Torres I M,et al.Biomarker-Based Nomogram to Predict Neoadjuvant Chemotherapy Response in Muscle-Invasive Bladder Cancer[J].Biomedicines,2025,13(3):740-740. [14] Shi Y,Fan G,Yang E,et al.Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder cancer[J].Materials Today Bio,2025,31101584-101584. [15] 符仕宝,陈宁,何书明,等.膀胱癌细胞外泌体诱导中性粒细胞外诱捕网形成对肿瘤细胞增殖､迁移和侵袭的研究[J].中国免疫学杂志,2025,41(02):351-356. [16] Bai Z,Osman M,Brendel M,et al.Predicting response to neoadjuvant chemotherapy in muscle-invasive bladder cancer via interpretable multimodal deep learning[J].npj Digital Medicine,2025,8(1):174-174. [17] 任翔,曾晓勇.2024年膀胱癌诊治进展[J].泌尿外科杂志(电子版),2025,17(01):22-30. [18] Ślusarczyk A,Scilipoti P,Marcq G,et al.Comparison of extended and standard lymph node dissection in radical cystectomy for urothelial bladder cancer:a systematic review and meta-analysis[J].World Journal of Urology,2025,43(1):181-181. [19] Liu C,Deng Y,Huang L,et al.USP5 Suppresses Ferroptosis in Bladder Cancer Through Stabilization of GPX4[J].Current Issues in Molecular Biology,2025,47(3):211-211. [20] 刘磊,张远鹏,樊继全,等.复发性膀胱癌的多学科联合诊疗及文献复习[J].临床泌尿外科杂志,2023,38(11):886-892. [21] Li P K,Wang L,Wan S,et al.Enhanced Artificial Intelligence in Bladder Cancer Management:A Comparative Analysis and Optimization Study of Multiple Large Language Models.[J].Journal of endourology,2025, [22] Aslan S,Tasdemir N M,Cakir E,et al.Predicting variant histology in bladder cancer:the role of multiparametric MRI and vesical imaging-reporting and data system(VI-RADS).[J].Abdominal radiology(New York),2025,(prepublish):1-12. [23] 张玲,刘艳梅,邓凤,等.“四精”护理模式在泌尿外科老年膀胱癌患者康复中的应用效果[J].泌尿外科杂志(电子版),2025, 17(01):94-97. [24] Li B,Gan J,Li T,et al.Comprehensive analysis of RNA methylation-related genes to identify molecular cluster for predicting prognosis and immune profiles in bladder cancer.[J].Scientific reports,2025,15(1):9147. [25] Thakur A,Kumar L,Agarwal S,et al.Assessing the clinical efficacy of neoadjuvant intravesical Mitomycin C in naïve non-muscle invasive urinary bladder cancer:A systematic review and meta-analysis.[J].Current problems in cancer,2025,101198.

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