新型炎症复合指标对急性缺血性脑卒中预后价值的研究进展

ISSN:2705-098X(P)

EISSN:2705-0505(O)

语言:中文

作者
韦文萍,韦 华
文章摘要
近年来,炎症反应在急性缺血性脑卒中(Acute ischemic stroke,AIS)病理机制中的作用日益受到关注。研究表明,炎症反应不仅贯穿AIS的整个病理过程,还在神经损伤、修复及预后中扮演重要角色。相比传统单一指标,新型复合炎性指标更全面、精准地反映炎症状态,在AIS预后评估中展现出较高临床价值。本文就基于新型免疫炎症标志物在AIS预后中的研究进展作一综述。
文章关键词
炎症;急性缺血性脑卒中;预后;免疫炎症标志物
参考文献
[1] Feigin V L,Brainin M,Norrving B,et al.World Stroke Organization:Global Stroke Fact Sheet 2025[J].Int J Stroke,2025,20(2):132-144. [2] Liu L,Li Z,Zhou H,et al.Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases:executive summary and 2023 update[J].Stroke Vasc Neurol,2023,8(6):e3. [3] 赵勃,尹其阳,李运曼.炎症在缺血性脑卒中的作用机制及抗炎药物治疗进展[J].药学进展,2021,45(02):145-152. [4] Zhang Z,Lv M,Zhou X,et al.Roles of peripheral immune cells in the recovery of neurological function after ischemic stroke[J].Front Cell Neurosci,2022,16:1013905. [5] 袁苏苏,贾锋.缺血性脑卒中后神经炎症的研究进展[J].同济大学学报(医学版),2024,45(04):591-599. [6] Wang C,Zhang Q,Ji M,et al.Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis:a systematic review and meta-analysis[J].BMC Neurol,2021,21(1):191. [7] Bai M,Sun R,Cao B,et al.Monocyte-related cytokines/chemokines in cerebral ischemic stroke[J].CNS Neurosci Ther,2023,29(12):3693-3712. [8] 钟辛,李燕华.T淋巴细胞免疫应答在缺血性脑卒中的研究进展[J].中华老年心脑血管病杂志,2022,24(10):1118-1120. [9] He S,Lei W,Li J,et al.Relation of Platelet Parameters With Incident Cardiovascular Disease(The Dongfeng-Tongji Cohort Study)[J].Am J Cardiol,2019,123(2):239-248. [10] 马雪飞,冯冬军,吕东,等.基于信号通路探讨缺血性脑卒中疾病的研究进展[J].牡丹江医学院学报,2021,42(05):128-131. [11] 徐焕昌,王雪梅.系统免疫炎症指数与急性缺血性脑卒中相关性研究进展[J].中国神经免疫学和神经病学杂志, 2023,30(04):277-281. [12] Hu B,Yang X R,Xu Y,et al.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma[J].Clin Cancer Res,2014,20(23):6212-6222. [13] Chu Y W,Chen P Y,Lin S K.Correlation between Immune-Inflammatory Markers and Clinical Features in Patients with Acute Ischemic Stroke[J].Acta Neurol Taiwan,2020,29(4):103-113. [14] Weng Y,Zeng T,Huang H,et al.Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis[J].Clin Interv Aging,2021,16:877-886. [15] Yi H J,Sung J H,Lee D H.Systemic Inflammation Response Index and Systemic Immune-Inflammation Index Are Associated with Clinical Outcomes in Patients Treated with Mechanical Thrombectomy for Large Artery Occlusion[J].World Neurosurg,2021,153:e282-e289. [16] Qian A,Zheng L,He H,et al.Predictive value of the systemic immune-inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy-a single-center study[J].Front Neurol,2024,15:1516577. [17] 滕旭升,傅亚明,盛孝燕.AFR和FPR与急性缺血性脑卒中患者临床预后的关系[J].浙江医学,2019,41(08):802-805. [18] Chen X,Xu X,Li Y,et al.Association between fibrinogen-to-albumin ratio and functional prognosis of 3 months in patients with acute ischemic stroke after intravenous thrombolysis[J].Brain Behav,2024,14(1):e3364. [19] Sun S,Cheng Y,Li L,et al.A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke[J].J Inflamm Res,2024,17:4151-4161. [20] Derya O,Onur U K,Miray E,et al.Fibrinogen to albumin ratio's prognostic value in ischemic stroke patients who underwent mechanical thrombectomy[J].Ideggyogy Sz,2024,77(5-6):167-176. [21] 张中华,黄清,刘春梅,等.纤维蛋白原/白蛋白比值预测老年急性缺血性卒中血管内治疗术后预后不良的价值[J].实用老年医学, 2021,35(03):241-245. [22] Bian J,Guo S,Huang T,et al.CRP as a potential predictor of outcome in acute ischemic stroke[J].Biomed Rep,2023,18(2):17. [23] Yang X,Wang L,Zheng L,et al.Serum Albumin as a Potential Predictor of Pneumonia after an Acute Ischemic Stroke[J].Curr Neurovasc Res,2020,17(4):385-393. [24] 胡超胜,王超,吴文波,等.血清PCT、CRP及CRP/Alb比值对老年缺血性脑卒中后卒中相关性肺炎的早期预测价值[J].分子诊断与治疗杂志,2022,14(05):879-882. [25] 王学成,许晓红,王中新.C反应蛋白/清蛋白比值与急性缺血性脑卒中严重程度相关性分析[J].国际检验医学杂志, 2023,44(06):749-751. [26] Xu T,Xia L,Wu Y,et al.High ratio of C-reactive protein to albumin is associated with hemorrhagic transformation and poor functional outcomes in acute ischemic stroke patients after thrombolysis[J].Front Aging Neurosci,2023,15:1109144. [27] Akpinar C K,Kocaturk O,Aykac O,et al.Can C-reactive protein/albumin ratio be a prognostic factor in acute stroke patients undergoing mechanical thrombectomy?[J].Clin Neurol Neurosurg,2023,231:107856. [28] Delibas K S,Ucan T F.Can the Neutrophil-to-Lymphocyte Ratio,Platelet-to-Lymphocyte Ratio,and C-Reactive Protein-to-Albumin Ratio Always Predict Mortality in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy?A Single-Center Experience[J].Brain Sci,2025,15(3):323.
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