马远航,沈有录

冠心病的发生发展与高血压、血脂异常、糖尿病及高尿酸血症密不可分。近些年来，炎症、冠状动脉钙化和心血管疾病之间复杂的病理联系逐渐带入大众视野,SII和冠心病及高危因素紧密联系，全身免疫炎症指数（SII）作为能够对患者全身炎症状况作出反应的敏感指标来评估冠心病预防、发展及其预后是一个良好的指标。同时，通过探究全身炎症免疫指数（SII）与冠状动脉钙化之间的关联，为临床预防和治疗冠状动脉钙化提供了新的思路和依据。

冠状动脉钙化；全身炎症免疫指数；心血管疾病；炎症反应；免疫调节

[1] 刘明波,王增武,樊静,等.《中国心血管健康与疾病报告2023》要点解读[J].中国心血管病研究,2024,22(07):577-593. [2] Libby P,Ridker PM,Hansson GK;Leducq Transatlantic Network on Atherothrombosis.Inflammation in atherosclerosis:from pathophy- siology to practice.J Am Coll Cardiol.2009 Dec 1;54(23):2129-38. [3] Marchi F､Pylypiv N､Parlanti A､Storti S､Gaggini M､Paradossi U､Berti S､Vassalle C.Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction临床医学杂志2024年2月22日;13(5):1256. [4] 李思源,周杰,张鸥,等.冠状动脉钙化的影响因素[J].中华老年多器官疾病杂志,2018,17(03):228-232. [5] SHEN J,ZHAO M,ZHANG C,et al.IL-1βin atherosclerotic vascular calcification:From bench to bedside[J].Int J Biol Sci,2021, 17(15):4353-4364. [6] Vergallo R,Liuzzo G.Coronary artery calcium scoring for cardiovascular risk stratification:more itfalls than advantages?.Eur Heart J.2022,43(37):3510-3511. [7] 郭伟民,肖传实.冠状动脉钙化及其程度与冠心病危险因素关系的研究[J].中国全科医学,2006,(14):1150-1152+1155. [8] WallinR,Wajih N,Greenwood GT,et al.Arterial calcification:a review of mechanisms,animal models,and the prospects for therapy[J],MedResRev,2001,21(4):274-301. [9] Andrews J,Psaltis PJ,Bartolo BAD,et al.Coronary arterial calcification:a review of mechanisms,promoters and imaging[J].Trends Cardiovasc Med,2018,28(8):491-501. [10] 谭静,李静,张迎花,等.冠状动脉早期粥样硬化症患者冠状动脉钙化的影响因素分析[J].首都医科大学学报,2020,41(06):978-981. [11] WallinR,Wajih N,Greenwood GT,et al.Arterial calcification:a review of mechanisms,animal models,and the prospects for therapy[J].MedResRev,2001,21(4):274-301. [12] Sakamoto A,Virmani R,Finn AV.Coronary artery calcification:recent developments in our understanding of its pathologic and clinical significance[J].CurrOpin Cardiol,2018,33(6):645-652. [13] Jing,Liu,Kun,et al.Inflammation Disrupts the LDL Receptor Pathway and Accelerates the Progression of Vascular Calcification in ESRD Patients[J].PLoSONE,2012,7(10):e47217. [14] 史红革,王志荣.高龄患者冠状动脉钙化情况及影响因素分析[J].中国煤炭工业医学杂志,2016,19(08):1095-1099. [15] 陈晓帅.血管内超声-OCT系统中超声成像技术的研究[D].天津大学,2018. [16] XU Y,MINTZ GS,TAM A,et al.Prevalence,distribution,predictors,and outcomes of patients with calcified nodules in native coronary arteries:a 3-vessel intravascular ultrasound analysis from Providing Regional Observations to Study Predictors of E-vents in the Coronary Tree(PROSPECT)[J].Circulation,2012,126(5):537-545. [17] JOO NS,JUNG S,KIN YN,et al.Cut-off value of serum homocysteine in relation to increase of coronary artery calcification[J]..J Investig Med,2021,69(2):345-350. [18] HU B,YANG X R,XU Y,et al.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma[J].Clinical Cancer Research,2014,20(23):6212-6222. [19] BALTA S,OZTURK C.The platelet lymphocyte ratio:a simple,inexpensive and rapid prognostic marker for cardiovascular events[J]. Platelets,2015,26(7):680-681. [20] Rasmussen SJ,Eckmann L,Quayle AJ,et al.Secretion of pro-inflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis[J].J Clin Invest,1997,99(1):77-87. [21] 黄小宇,张丽晖,王静,等.全身免疫炎症指数与心血管疾病相关性的研究进展[J].中西医结合心脑血管病杂志,2024,22(07):1266-1269. [22] Horne BD,Anderson JL,John JM,et al.Which white blood cell subtypes predict increased cardiovascular risk.J Am Coll Cardiol.2005; 45(10):1638-1643. [23] Mehu,M.;Narasimhulu,C.A.;Singla,D.K.Inflammatory Cells in Atherosclerosis.Antioxidants 2022,11,233. [24] VENKATRAGHAVAN L,TAN T P,MEHTA J,et al.Neutrophil lymphocyte ratio as a predictor of systemic inflammation-Across- sectional study in a pre-admission setting[J].F1000 Research,2015,4:123.

点击下载PDF