李 彬,黄菊芳,梁舒琪

多糖由于良好的生物相容性，低毒。多糖还可以激活巨噬细胞、T淋巴细胞、B淋巴细胞和自然杀伤细胞（NK细胞），促进细胞因子生成和抗体的产生。多糖佐剂是一类由多糖（polysaccharides）组成的免疫佐剂，通过激活补体系统，从而提高机体免疫力能够增强疫苗或药物的免疫效果。它们主要通过激活机体的先天免疫系统，调节免疫细胞的反应，从而增强抗体生成、细胞介导的免疫反应等。因此在免疫佐剂等领域得到了广泛应用。本综述介绍了常见的佐剂类型；多糖佐剂的机制；常见的多糖佐剂。

佐剂；多糖；免疫佐剂；机制

[1] 霍宇娟,郑源强,崔正荣石艳春.铝盐佐剂的安全性思考.中国免疫学杂志2019(第6期):753-759. [2] O'Hagan DT,Valiante NM.Recent advances in the discovery and delivery of vaccine adjuvants.Nat Rev Drug Discov 2003,2(9):727-735. [3] Gregoriadis G.Liposomes in drug delivery:how it all happened.In:MDPI;2016.p.19. [4] Muzzarelli RA.Chitosan-based dietary foods.Carbohydr Polym 1996,29(4):309-316. [5] Peppas NA,Bures P,Leobandung WS,Ichikawa H.Hydrogels in pharmaceutical formulations.Eur J Pharm Biopharm 2000,50(1):27-46. [6] Grgacic EV,Anderson DA.Virus-like particles:passport to immune recognition.Methods 2006,40(1):60-65. [7] Pati R,Shevtsov M,Sonawane A.Nanoparticle vaccines against infectious diseases.Front Immunol 2018,9:2224. [8] 崔倩倩,周志勇,刘朝奇,袁丁.植物多糖作为免疫佐剂的研究进展.时珍国医国药2015(第4期):970-972. [9] Takeuchi O,Akira S.Pattern recognition receptors and inflammation.Cell 2010,140(6):805-820. [10] De Gregorio E,Rappuoli R.Vaccines for the future:learning from human immunology.Microb Biotechnol 2012,5(2):149-155. [11] Yang S,Dong W,Li G,Zhao Z,Song M,Huang Z,Fu J,Jia F,Lin S.A recombinant vaccine of Riemerella anatipestifer OmpA fused with duck IgY Fc and Schisandra chinensis polysaccharide adjuvant enhance protective immune response.Microb Pathog 2019,136:103707. [12] Feng H,Fan J,Qiu H,Wang Z,Yan Z,Yuan L,Guan L,Du X,Song Z,Han X.Chuanminshen violaceum polysaccharides improve the immune responses of foot-and-mouth disease vaccine in mice.Int J Biol Macromol 2015,78:405-416. [13] Zhang W,Cheng N,Wang Y,Zheng X,Zhao Y,Wang H,Wang C,Han Q,Gao Y,Shan J.Adjuvant activity of PCP-II,a polysaccharide from Poria cocos,on a whole killed rabies vaccine.Virus Res 2019,270:197638. [14] Liu Y,Zhang S,Zhang F,Hu R.Adjuvant activity of Chinese herbal polysaccharides in inactivated veterinary rabies vaccines.Int J Biol Macromol 2012,50(3):598-602. [15] 梁艳,黄恋,常海艳,陈则,方芳.人参多糖对新甲型h1n1流感病毒灭活疫苗的免疫增强作用.激光生物学报2012(第1期):36-41.

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