铁死亡是一种铁依赖性的新型细胞死亡方式，近年的相关研究发现其独特的代谢特征和调控机制在多种肿瘤疾病的发生、发展中发挥了关键作用，研究表明，靶向铁死亡通路可能为食管癌治疗提供新的思路和方法，但仍需进一步研究以克服当前面临的挑战，本文详细阐述了铁死亡的核心机制、在食管癌中的双重作用、相关治疗策略以及面临的挑战。

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