张艺琳,李晓平

慢性阻塞性肺疾病（COPD）是一种常见的可以预防和治疗的呼吸系统疾病，主要有慢性咳嗽、咳痰和呼吸困难等症状。其发病率、致残率及死亡率都在逐年升高。关于COPD的发病机制目前还需要进一步研究。目前关于其机制的主要研究热点有氧化/抗氧化失衡、蛋白酶/抗蛋白酶失衡，慢性气道炎症反应等多个方面，特别值得关注的是炎症反应。Th17/Treg比例、SCFAs的变化与多种疾病密切相关，如自身免疫性疾病，慢性炎症，肿瘤等。本文就Th17/Treg比例、SCFAs的变化与COPD的发病机制之间的相关性进行综述。

COPD；Th17/Treg；SCFAs

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