张 曼,孙 静,保善茵,刘成娟,许慧宁

青年性脑梗死的发病率逐年上升，因其病因复杂且异质性强，早期诊断和预后评估面临挑战，且严重影响患者生活质量及预后，从而受到广泛关注。目前，对青年性脑梗死的早期诊断及预后评估主要依靠临床评估及神经影像学，鲜有客观简单、便捷的快速预测工具。本文综述了近年来外周血生物标志物在青年性脑梗死领域中的研究进展，重点探讨了炎症标志物（如CRP、IL-6）、凝血功能标志物（如D-二聚体、纤维蛋白原）等以及新型生物标志物（如miRNA、外泌体）与青年性脑梗死的发生发展、严重程度及预后的相关性。此外，本文还分析了目前研究中存在的局限性，并对未来研究方向进行了展望，以期为青年性脑梗死的早期诊断、个体化治疗以及预后评估提供新的思路和依据。

青年性脑梗死；外周血生物标志物；早期诊断；预后评估

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