牛玉婷,杨勇莉

子宫内膜癌（endometrial carcinoma，EC）是女性生殖系统第二常见的恶性肿瘤，且发病率和死亡率逐年上升[1]。近年来，随着人们饮食习惯及生活方式的改变，高血脂症的发病率逐渐增加。循证医学研究表明，高脂血症可促进乳腺癌、卵巢癌、EC等恶性肿瘤的发生和发展[2]。目前多数研究认为血脂对于EC的影响可能是通过PI3K/AKT通路、雌激素、ROS等途径产生的[3]。本文针对血脂与EC的关系、发生机制及降脂药物对EC的影响进行综述，进一步为针对脂质代谢异常的EC患者开辟新的治疗方法及为后期的研究提供参考。

子宫内膜癌；血脂；病因关系；降脂药物

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