黄 玲,谢思明

口腔鳞状细胞癌（Oral squamous cell carcinoma，OSCC）和糖尿病是当前重要的公共卫生问题。AGEs（Advanced glycation end-product，晚期糖基化终末产物）通过其受体RAGE（Receptor for Advanced Glycation End Products，晚期糖基化终末产物受体）激活多条细胞信号传导路径，包括NF-κB、MAPK、PI3K/Akt、JAK/STAT等，促进炎症反应、细胞增殖、迁移和存活，进而加速癌症的进展和糖尿病并发症的恶化。本文综述了RAGE及其信号通路在OSCC中的作用机制，探讨了抑制这些信号通路作为潜在治疗策略的可行性。

口腔鳞状细胞癌；晚期糖基化终末产物；晚期糖基化终末产物受体；信号通路

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