鲁 艳,杨焕娟,李英兰

在本综述中，我们将从慢性阻塞性肺疾病合并肺栓塞的临床表现、诊断和治疗等方面展开论述，以便于临床上更准确地诊断、精准识别而后提供及时有效的治疗，从而改善此类患者的预后。

慢性阻塞性肺病；肺栓塞；诊断；治疗

[1] Brightling C E.Chronic obstructive pulmonary disease phenotypes,biomarkers,and prognostic indicators[J].Allergy&Asthma Procee- dings,2016,37(6):432. [2] FU X,ZHONG Y,XU W,et al.The prevalence and clinical features of pulmonary embolism in patients with AE-COPD:A meta-analysis and systematic review[J].PLoS One,2021,16(9):1-14. [3] Aleva FE,Voets LWLM,Simons SO,de Mast Q,van der Ven AJAM,Heijdra YF.Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD:A Systematic Review and Meta-analysis.Chest.2017 Mar;151(3):544-554. [4] Akhoundi N,Amirbakhtiarvand M,Goli M,Naseri Z,Siami A.Assessing the Prevalence of Pulmonary Embolism and the Clot Burden in Hospitalized Patients with Chronic Obstructive Pulmonary Disease Exacerbation.Thorac Res Pract.2024Mar;25(2):57-61. [5] Muñoz Rodríguez FJ.Diagnosis of deep vein thrombosis.Rev Clin Esp.2020 Jun 27:S0014-2565(20)30132-6.English,Spanish. [6] 刘忠强,周翔,周东霞.COPD急性加重患者的肺栓塞危险因素分析及预测模型构建[J].浙江临床医学,2024,26(5):661-664. [7] Fu X,Zhong Y,Xu W,Ju J,Yu M,Ge M,Gu X,Chen Q,Sun Y,Huang H,Shen L.The prevalence and clinical features of pulmonary embolism in patients with AE-COPD:A meta-analysis and systematic review. PLoS One.2021 Sep 2;16(9):e0256480. [8] Tsao C.W.,Aday A.W.,Almarzooq Z.I.,Alonso A.,Beaton A.Z.,Bittencourt M.S.,Boehme A.K.,Buxton A.E.,Carson A.P.,Commodore- Mensah Y.,et al.Heart Disease and Stroke Statistics-2022 Update:A Report from the American Heart Association. Circulation. 2022; 145:e153–e639. [9] Peng L,Han L,Li XN,Miao YF,Xue F,Zhou C.The Predictive Value of microRNA-134 and microRNA-1233 for the Early Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Pulmonary Embolism.Int J Chron Obstruct Pulmon Dis.2020 Oct 15;15:2495-2503. [10] Yang R,Liu G,Deng C.Pulmonary embolism with chronic obstructive pulmonary disease.Chronic Dis Transl Med.2021 Jun 24;7(3):149-156. [11] 郑宝华,乐香珠,温小梅.慢性阻塞性肺疾病急性加重合并肺栓塞D-二聚体检测的诊断价值[J].临床合理用药杂志,2020,13(26):173-174. [12] Naum AG,Jari I,Moisii L,Ursu AM,Moisii P.Imaging and Biomarkers:The Assesment of Pulmonary Embolism Risk and Early Mortality.Medicina(Kaunas).2024 Sep 12;60(9):1489. [13] Falster C.,Hellfritzsch M.,Gaist T.A.,Brabrand M.,Bhatnagar R.,Nybo M.,Andersen N.H.,Egholm G.Comparison of international guideline recommendations for the diagnosis of pulmonary embolism.Lancet Haematol.2023;10:e922–e935. [14] Mai V,Girardi L,de Wit K,Castellucci L,Aaron S,Couturaud F,Fergusson DA,Le Gal G.Chronic obstructive pulmonary disease exacer- bation purulence status and its association with pulmonary embolism:protocol for a systematic review with meta-analysis.BMJ Open.2024 Jun 19;14(6):e085328. [15] 孙剑萍,赵新国,潘健,等.心电图与超声心动图诊断急性肺栓塞[J].临床心电学杂志,2014,23(2):114-117. [16] 周丽莉.心脏彩超检查在肺动脉高压诊断中的应用价值[J].中国卫生标准管理,2020,11(15):119-120. [17] 武艳娇,申海龙,翟江,等.心脏彩超对AECOPD并发肺栓塞的评估价值[J].影像科学与光化学,2022,40(01):109-113. [18] Gutmann C,Siow R,Gwozdz AM,et al.Reactive oxygen species in venous thrombosis[J].Int J Mol Sci,2020,21(6):1918. [19] Wang Q,Zennadi R.Oxidative stress and thrombosis during aging:the roles of oxidative stress in RBCs in venous thrombosis[J].Int J Mol Sci,2020,21(12):4259. [20] 吴彤,林盪.嗜酸性粒细胞及其生物学标志物对慢性阻塞性肺疾病急性加重期合并肺栓塞的诊断价值[J].江苏医药,2023,49(09):962-966. [21] Montagnana M.,Cervellin G.,Meschi T.,Lippi G.The role of red blood cell distribution width in cardiovascular and thrombotic disorders.Clinical Chemistry and Laboratory Medicine.2012; 50(4):635–641. [22] Wang J,Wan Z,Liu Q,Wang B,Wang L,Yang D,Wang L,Hong Y,Zhu R.Predictive Value of Red Blood Cell Distribution Width in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Embolism.Anal Cell Pathol(Amst).2020 Jul 21;2020:1935742. [23] Yu R,Kong X,Li Y.Optimizing the Diagnostic Algorithm for Pulmonary Embolism in Acute COPD Exacerbation Using Fuzzy Rough Sets and Support Vector Machine.COPD.2023 Dec;20(1):1-8. [24] Gao N,Tian S,Li X,et al.Three-dimensional texture feature analysis of pulmonary nodules in CT images:lung cancer predictive models based on support vector machine classifier.J Digit Imaging.2020;33(2):414–422. [25] 彭丽娜,李彩霞.慢性阻塞性肺疾病急性加重期患者并发肺栓塞的危险因素分析[J].现代医学与健康研究(电子版),2022, 6(14):128-131. [26] Lai J,Feng S,Xu S,Liu X.Effects of oral anticoagulant therapy in patients with pulmonary diseases.Front Cardiovasc Med.2022 Aug 10;9:987652. [27] 周晓燕.低分子肝素联合华法林对慢性阻塞性肺病伴肺栓塞患者的治疗效果[J].慢性病学杂志,2023,24(2):253-256. [28] 季楠,俞敏,林盪.慢性阻塞性肺疾病合并肺栓塞的相关性研究进展[J].心肺血管病杂志,2022,41(2):210-213,209.

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